MTHFD1L Products

Antibodies
MTHFD1L Antibody
MTHFD1L Antibody
NBP2-46781
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
MTHFD1L Antibody
MTHFD1L Antibody
NBP2-37863
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
MTHFD1L Antibody
MTHFD1L Antibody
NBP2-37864
Species: Hu, Mu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Proteins
Recombinant Human MTHFD1L Pro ...
Recombinant Human MTHFD1L Protein
H00025902-Q01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human MTHFD1L Pro ...
Recombinant Human MTHFD1L Protein
H00025902-P01
Species: Hu
Applications: WB, ELISA, PA
MTHFD1L Recombinant Protein A ...
MTHFD1L Recombinant Protein Antigen
NBP2-57852PEP
Species: Hu
Applications: AC
RNAi
MTHFD1L RNAi
MTHFD1L RNAi
H00025902-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

MTHFD1L, also known as Monofunctional C1-tetrahydrofolate synthase, mitochondrial, consists of 2 a 978 amino acid isoform1 that is 106 kDa and a 275 amino acid isoform 2 that is 30 kDa; has mitochondrion subcellular location and highest expression found in placenta, thymus and brain; it is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion which is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine, and also may provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. Current research is being performed on this protein involvement in cleft lip/palate, neural tube defect, homocysteine, coronary heart disease, chronic myeloid leukemia, Down syndrome, colon adenocarcinoma, nephropathy, Alzheimer's disease, dementia, colorectal cancer, leukemia, and atherosclerosis. This protein plays role in One carbon pool by folate and Metabolic pathways where it interacts with CASP4, MAGED1, WRAP73, WDR8, MAP1LC3A, and plus more than 40 other proteins.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 25902
Alternate Names
  • Formyltetrahydrofolate synthetase
  • 10-formyl-THF synthetase
  • monofunctional C1-tetrahydrofolate synthase, mitochondrial
  • DKFZP586G1517
  • mitochondrial C1-tetrahydrofolate synthetase
  • EC 6.3.4.3
  • mitochondrial C1-tetrahydrofolate synthase
  • FTHFSDC1
  • dJ292B18.2
  • formyltetrahydrofolate synthetase domain containing 1
  • MTC1THFS
  • FLJ21145
  • DKFZp586G1517
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

Pathways for MTHFD1L

View related products by pathway and learn more about each of the pathways below.

Methylation
Mrna Splicing
Cell Proliferation
Cell Cycle
Dna Methylation

PTMs for MTHFD1L

Learn more about PTMs related to MTHFD1L.

Methylation

Bioinformatics Tool for MTHFD1L

Discover related pathways, diseases and genes to MTHFD1L. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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