MSK1/RPS6KA5 Products

Description

MSK-1 is a mitogen and stress activated protein kinase-1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK-1can be activated by ERK1/2 and SAPK2 /p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG-14 in response to mitogen and stress (1-2). Similar to RSK, MSK-1 contains two kinase domains (N-term and a C-term) (3). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK-1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C-terminal kinase domain of MSK-1 which is essential for the catalytic activity of the N-terminal kinase domain (4).

Bioinformatics

Entrez	73086 Mouse 9252 Human
Uniprot	AAH17187 Human AAH17187.1 Human NM_182398 Human NP_004746 Human NP_004746.2 Human O75582 Human
Product By Gene ID	9252
Alternate Names	EC 2.7.11 MGC1911,90 kDa ribosomal protein S6 kinase 5 MSK1EC 2.7.11.1 MSPK1 Nuclear mitogen- and stress-activated protein kinase 1 ribosomal protein S6 kinase alpha-5 ribosomal protein S6 kinase, 90kD, polypeptide 5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 RLPK RSKL RSK-like protein kinase S6K-alpha-5

Research Areas for MSK1/RPS6KA5

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase
Signal Transduction