MKK7/MEK7 Products

Description

c-Jun NH2-terminal protein kinase (JNK), a distant member of the mitogen-activated protein (MAP) kinase family, regulates gene expression in response to various extracellular stimuli. MKK7, a novel member of the MAP kinase kinase family, was phosphorylated and activated by MEKK1, a MAP kinase kinase kinase in the JNK signaling cascade. MKK7 activity was also stimulated by constitutively active forms of Rac and Cdc42Hs, members of the Rho small GTP-binding protein family (1). endogenous MKK7 was activated by treatment with the growth factor interleukin-3 (but not interleukin-4), or by ligation of CD40, the B-cell antigen receptor, or the receptor for the Fc fragment of immunoglobulin. MKK7 was also activated when cells were exposed to heat, UV irradiation, anisomycin, hyperosmolarity or the pro-inflammatory cytokine tumor necrosis factor-alpha, suggesting that MKK7 is involved in many physiological pathways (2).

Bioinformatics

Entrez	26400 Mouse 363855 Rat 5609 Human
Uniprot	AAH38295.1 Human NP_660186 Human O14733 Human
Product By Gene ID	5609
Alternate Names	c-Jun N-terminal kinase kinase 2 dual specificity mitogen-activated protein kinase kinase 7 EC 2.7.12.2 JNK kinase 2 JNK-activating kinase 2 JNKK 2 JNKK2 Jnkk2 MAP kinase kinase 7 MAPK/ERK kinase 7 MAPKK7 MEK 7 MEK7 mitogen-activated protein kinase kinase 7 MKK7MAPKK 7 PRKMK7

Research Areas for MKK7/MEK7

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Protein Kinase