MITF Products

Antibodies
MITF Antibody (JF100-01)
MITF Antibody (JF100-01)
NBP2-66951
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF
Host: Rabbit Monoclonal
MITF Antibody (MITF/915)
MITF Antibody (MITF/915)
NBP2-45161
Species: Hu, Ca, Mu(-), Rt(-)
Applications: Flow, IHC, IHC-P, ICC/IF
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
Lysates
MITF Overexpression Lysate
MITF Overexpression Lysate
NBP2-09070
Species: Hu
Applications: WB
Proteins
Recombinant Human MITF GST (N ...
Recombinant Human MITF GST (N-Term...
H00004286-P02
Species: Hu
Applications: WB, ELISA, PA, AP
MITF Recombinant Protein Anti ...
MITF Recombinant Protein Antigen
NBP1-88618PEP
Species: Hu
Applications: AC

Description

MITF (microphthalmia-associated transcription factor) is a melanocytic nuclear protein that contains basic helix-loop-helix (HLH) and leucine zipper (LZ) domains. These protein motifs are frequently observed in other transcription factors and are particularly common to members of the Myc family. MITF can directly associate with DNA as a homodimer. It is required for the development and differentiation of melanocytes. Its expression is upregulated by cAMP and cAMP dependent pathways. MITF activates several different gene promoters by binding to their E-boxes. Tyrosinase, TRP-1 and TRP-2 are pigment synthesis genes activated by MITF. When MITF is phosphorylated on Serine 73 (via the MAPK pathway), it associates with coactivators of the p300/CBP family and enhances transcription. MITF has several isoforms including MITF-M which is specifically expressed in melanocytes. In Mitfdeficient mice there is a complete absence of melanocytes.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 4286
Alternate Names
  • WS2A
  • BHLHE32
  • Class E basic helix-loop-helix protein 32
  • bHLHe32MI
  • Waardenburg syndrome, type 2A
  • microphthalmia-associated transcription factor

Bioinformatics Tool for MITF

Discover related pathways, diseases and genes to MITF. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

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