MITF Products

Antibodies
MITF Antibody
MITF Antibody
AF5769
Species: Hu
Applications: WB, IHC
Host: Goat Polyclonal
MITF Antibody
MITF Antibody
NBP1-88618
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Antibody Pairs
MITF Antibody Pair
MITF Antibody Pair
H00004286-PW1
Species: Hu
Applications: WB, IP
Lysates
MITF Overexpression Lysate (N ...
MITF Overexpression Lysate (Native)
NBP2-09070
Applications: WB
MITF Overexpression Lysate (N ...
MITF Overexpression Lysate (Native)
NBL1-13118
Applications: WB
MITF Overexpression Lysate (D ...
MITF Overexpression Lysate (Denatu...
H00004286-T01
Applications: WB
Proteins
MITF Recombinant Protein
MITF Recombinant Protein
H00004286-P02
Species: Hu
Applications: WB, ELISA, PA
MITF Recombinant Protein Anti ...
MITF Recombinant Protein Antigen
NBP1-88618PEP
Species: Hu
Applications: AC
RNAi
MITF RNAi
MITF RNAi
H00004286-R04
Species: Hu
MITF RNAi
MITF RNAi
H00004286-R03
Species: Hu
MITF RNAi
MITF RNAi
H00004286-R05
Species: Hu

Description

MITF (microphthalmia-associated transcription factor) is a melanocytic nuclear protein that contains basic helix-loop-helix (HLH) and leucine zipper (LZ) domains. These protein motifs are frequently observed in other transcription factors and are particularly common to members of the Myc family. MITF can directly associate with DNA as a homodimer. It is required for the development and differentiation of melanocytes. Its expression is upregulated by cAMP and cAMP dependent pathways. MITF activates several different gene promoters by binding to their E-boxes. Tyrosinase, TRP-1 and TRP-2 are pigment synthesis genes activated by MITF. When MITF is phosphorylated on Serine 73 (via the MAPK pathway), it associates with coactivators of the p300/CBP family and enhances transcription. MITF has several isoforms including MITF-M which is specifically expressed in melanocytes. In Mitfdeficient mice there is a complete absence of melanocytes.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 4286
Alternate Names
  • WS2A
  • BHLHE32
  • Class E basic helix-loop-helix protein 32
  • bHLHe32MI
  • Waardenburg syndrome, type 2A
  • microphthalmia-associated transcription factor

Bioinformatics Tool for MITF

Discover related pathways, diseases and genes to MITF. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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