MED14 Products

Description

Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene.  The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo.  Chimera RNAi has many advantages over the conventional siRNAs.  First, it has been demonstrated to have reliable knock-down for over 10,000 human genes.  Because the human genome is composed of an intricate, genetic network, chimera RNAi's unique design has successfully obviated the off-target effects including microRNA-based influence.  Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected.  Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.

Bioinformatics

Product By Gene ID

9282

Alternate Names

Activator-recruited cofactor 150 kDa component ARC150 Cofactor required for Sp1 transcriptional activation subunit 2 cofactor required for Sp1 transcriptional activation, subunit 2 (150kD) CRSP150 CRSP2cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa CSRP CXorf4MGC104513 EXLM1CRSP complex subunit 2 human homolog of yeast RGR1 mediator complex subunit 14DRIP150 mediator of RNA polymerase II transcription subunit 14 RGR1RGR1 homolog Thyroid hormone receptor-associated protein complex 170 kDa component thyroid hormone receptor-associated protein complex component TRAP170 Transcriptional coactivator CRSP150 transcriptional co-activator CRSP150 Trap170 TRAP170hRGR1 vitamin D receptor-interacting protein complex component DRIP150 Vitamin D3 receptor-interacting protein complex 150 kDa component

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