MED14 Products

Description

The activation of gene transcription is a multi-step process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multi-subunit complexes e.g. thyroid hormone receptor (TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.

Bioinformatics

Entrez	26896 Mouse 9282 Human
Uniprot	O60244 Human
Product By Gene ID	9282
Alternate Names	Activator-recruited cofactor 150 kDa component ARC150 Cofactor required for Sp1 transcriptional activation subunit 2 cofactor required for Sp1 transcriptional activation, subunit 2 (150kD) CRSP150 CRSP2cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa CSRP CXorf4MGC104513 EXLM1CRSP complex subunit 2 human homolog of yeast RGR1 mediator complex subunit 14DRIP150 mediator of RNA polymerase II transcription subunit 14 RGR1RGR1 homolog Thyroid hormone receptor-associated protein complex 170 kDa component thyroid hormone receptor-associated protein complex component TRAP170 Transcriptional coactivator CRSP150 transcriptional co-activator CRSP150 Trap170 TRAP170hRGR1 vitamin D receptor-interacting protein complex component DRIP150 Vitamin D3 receptor-interacting protein complex 150 kDa component

Research Areas for MED14

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction