MED12 Products

Recombinant Human MED12 GST ( ...
Recombinant Human MED12 GST (N-Ter...
Species: Hu
Applications: WB, ELISA, PA, AP


The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. (provided by RefSeq)


Entrez Human
Uniprot Human
Product By Gene ID 9968
Alternate Names
  • Trap230
  • CAG repeat protein 45
  • trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit)
  • ARC240
  • thyroid hormone receptor-associated protein, 230 kDa subunit
  • Trinucleotide repeat-containing gene 11 protein
  • OKSsubunit 12 homolog
  • CAGH45trinucleotide repeat containing 11 (THR-associated protein, 230kDa subunit)
  • TRAP230mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae)
  • KIAA0192FG syndrome 1
  • mediator complex subunit 12OPA-containing protein

Research Areas for MED12

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Signal Transduction

PTMs for MED12

Learn more about PTMs related to MED12.


Bioinformatics Tool for MED12

Discover related pathways, diseases and genes to MED12. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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