MED12 Products

Description

The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. (provided by RefSeq)

Bioinformatics

Entrez	59024 Mouse 9968 Human
Uniprot	NP_005111 Human Q93074 Human
Product By Gene ID	9968
Alternate Names	ARC240 CAG repeat protein 45 CAGH45trinucleotide repeat containing 11 (THR-associated protein, 230kDa subunit) HOPAFGS1 KIAA0192FG syndrome 1 mediator complex subunit 12OPA-containing protein OKSsubunit 12 homolog thyroid hormone receptor-associated protein, 230 kDa subunit Trap230 TRAP230mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae) trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit) Trinucleotide repeat-containing gene 11 protein

Research Areas for MED12

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction
Vision