MDMX Products

Description

The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2

Bioinformatics

Entrez	4194 Human
Uniprot	NP_002384
Product By Gene ID	4194
Alternate Names	DKFZp781B1423 double minute 4 homolog Double minute 4 protein double minute 4, human homolog of; p53-binding protein HDMX Mdm2-like p53-binding protein Mdm4 p53 binding protein homolog (mouse) MDM4 Regulator of P53 MDM4 Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse) Mdm4, transformed 3T3 cell double minute 4, p53 binding protein MDM4-related protein 1 MDMX MDMXMGC132766 mouse double minute 4, human homolog of; p53-binding protein MRP1 p53-binding protein Mdm4 protein Mdm4 Protein Mdmx

Research Areas for MDMX

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Apoptosis