WB, IHC, IHC-Fr, IHC-P, IPHost:
Hu, Mu, RtApplications:
WB, ELISA, ICC/IF, IHC, IHC-PHost:
WB, ELISA, IP, PA
Applications: WB, ELISA, PA
Applications: WB, RNAi SP
MDM2 is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.
Bioinformatics Tool for MDM2/HDM2
Discover related pathways, diseases and genes to MDM2/HDM2. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.