MDM2/HDM2 Products

Antibodies
MDM2/HDM2 Antibody
MDM2/HDM2 Antibody
AF1244
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Rabbit Polyclonal
Conjugate Catalog # Availability Size Price
MDM2/HDM2 Antibody
MDM2/HDM2 Antibody
NBP1-67627
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
MDM2/HDM2 Overexpression Lysa ...
MDM2/HDM2 Overexpression Lysate (N...
NBL1-12970
Applications: WB
MDM2/HDM2 Overexpression Lysa ...
MDM2/HDM2 Overexpression Lysate (D...
H00004193-T01
Applications: WB
Proteins
MDM2/HDM2 Recombinant Protein ...
MDM2/HDM2 Recombinant Protein
H00004193-P01
Species: Hu
Applications: WB, ELISA, IP, PA
MDM2/HDM2 Partial Recombinant ...
MDM2/HDM2 Partial Recombinant Protein
H00004193-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
MDM2/HDM2 RNAi
MDM2/HDM2 RNAi
H00004193-R01V
Species: Hu
Applications: WB, RNAi SP
MDM2/HDM2 RNAi
MDM2/HDM2 RNAi
H00004193-R05
Species: Hu
MDM2/HDM2 RNAi
MDM2/HDM2 RNAi
H00004193-R03
Species: Hu

Description

MDM2 is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 4193
Alternate Names
  • ACTFS
  • HDM2
  • MDM2 oncogene, E3 ubiquitin protein ligase
  • HDMX

Research Areas for MDM2/HDM2

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Cellular Markers
Hypoxia
Neuroscience
p53 Pathway
Phospho-Specific
Tumor Suppressors

Bioinformatics Tool for MDM2/HDM2

Discover related pathways, diseases and genes to MDM2/HDM2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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