MCM5 Products

Description

MCM5 (Mini Chromosome Maintenance protein-5) is involved in the control of DNA replication. MCM proteins have DNA dependent ATPase motifs in their central domain which is conserved from yeast to mammals. MCM proteins form a complex which exhibits ATPase and helicase activities. In G0 phase levels of MCM 2 and 5 are lower than that of MCM7 and 3 but increase as the cell enters G1/S phase of the cell cycle. It has been reported that immunocytochemical assessment of Mcm5 expression may be of value in improving the accuracy of cervical smear testing for the detection of malignancy.

Bioinformatics

Entrez	4174 Human
Uniprot	AAH00142 Human NM_006739 Human NP_006730.2 Human P33992 Human
Product By Gene ID	4174
Alternate Names	CDC46 homolog CDC46DNA replication licensing factor MCM5 EC 3.6.4.12 MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S.cerevisiae) MCM5 minichromosome maintenance deficient 5, cell division cycle 46 MGC5315 minichromosome maintenance complex component 5 minichromosome maintenance deficient (S. cerevisiae) 5 (cell division cycle 46) minichromosome maintenance deficient 5 (cell division cycle 46) P1-CDC46

Diseases related to MCM5

Discover more about diseases related to MCM5.

Malignant Neoplasms
Neoplasms
Carcinoma
Malignant Paraganglionic Neoplasm
Malignant Neoplasm Of Urinary Bladder
Dysplasia
Cell Transformation, Neoplastic
Adenocarcinoma
Bladder Neoplasm
Malignant Squamous Cell Neoplasm
Uterine Cervical Neoplasm
Malignant Tumor Of Cervix
Malignant Neoplasm Of Prostate
Retinoblastoma
Intraepithelial Neoplasia
Genomic Instability
Cervical Intraepithelial Neoplasia
Esophageal Neoplasms
Prostatic Neoplasms
Neoplasm Metastasis

Pathways for MCM5

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Dna Replication
Cell Cycle
S Phase
Cell Proliferation
Localization
Mitosis
G1 Phase
M Phase
Cell Division
Cell Cycle Arrest
Regulation Of Dna Replication
Cell Death
Cell Growth
Dna Replication Initiation
Interphase
Pathogenesis
Dna Repair
Single-stranded Dna Binding
Neurogenesis
Anaphase

Research Areas for MCM5

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Cancer
Cell Cycle and Replication
Core ESC-Like Genes
DNA Repair
Stem Cell Markers

PTMs for MCM5

Learn more about PTMs related to MCM5.

Phosphorylation
Dephosphorylation
Biotinylation
Acetylation
Methylation

Bioinformatics Tool for MCM5

Discover related pathways, diseases and genes to MCM5. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.