MAPKAP Kinase 3 Products

Description

MAPKAP Kinase 3 encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.

Bioinformatics

Entrez	26417 Mouse 50689 Rat 7867 Human
Uniprot	AAH01662 Human NM_004635 Human NP_004626 Human NP_004626.1 Human Q16644 Human
Product By Gene ID	7867
Alternate Names	3PKEC 2.7.11.1 Chromosome 3p kinase EC 2.7.11 MAP kinase-activated protein kinase 3 MAPK-activated protein kinase 3 MAPKAP kinase 3 MAPKAP33pK MAPKAPK-3 mitogen-activated protein kinase-activated protein kinase 3

Research Areas for MAPKAP Kinase 3

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Protein Kinase