MAGI2 Products

Description

The membrane-associated guanylate kinase (MAGUK) proteins are concentrated at the membrane-cytoskeletal interface where they facilitate the assembly of multiprotein complexes on the inner surface of the plasma membrane. Three protein-protein interaction modules characteristically define MAGUK related proteins: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain. The closely related MAGUK proteins, MAGI-1, MAGI-2 and MAGI-3 (membrane associated guanylate kinase inverted-1 and 2), likewise contain the GuK domain and five PDZ domains; however, the SH3 domain is replaced with a WW domain. The transcripts of MAGI-1 are alternatively spliced to produce three distinct proteins having unique carboxy-terminals. Two variants, MAGI-1a and MAGI-1b, are associated with the membrane and cytosolic fractions and are primarily expressed in the brain. The third isoform, MAGI-1c, encodes for a nuclear localization signal that localizes MAGI-1c to the nucleus, and it is primarily expressed in the liver and kidney. MAGI-2 and MAGI-3 are localized to the plasma membrane, and they contribute to protein scaffolding by associating with the protein phosphatase PTEN.

Bioinformatics

Entrez	9863 Human 50791 Mouse 113970 Rat
Uniprot	Q86UL8 Human
Product By Gene ID	9863
Alternate Names	ACVRINP1 ACVRIP1 AIP1 AIP1AIP-1 ARIP1 atrophin 1 interacting protein 1 atrophin-1 interacting protein A Atrophin-1-interacting protein 1 Atrophin-1-interacting protein A KIAA0705activin receptor interacting protein 1 MAGI2 MAGI-2SSCAM membrane associated guanylate kinase, WW and PDZ domain containing 2 Membrane-associated guanylate kinase inverted 2 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 SSCAM