MAG/Siglec-4a Products

Description

Myelin-associated glycoprotein (MAG), a membrane glycoprotein of 100 kDa, is thought to be involved in the process of myelination (1). Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in myelin, Nogo and MAG (2). MAG has been implicated in inhibition of nerve regeneration in the CNS. This results from interactions between MAG and the Nogo receptor and gangliosides on the apposing axon, which generates intracellular inhibitory signals in the neuron (3). Results also suggest that MAG binds to a specific receptor and initiates a signal transduction cascade to effect inhibition. These results indicate that soluble dMAG detected in vivo could contribute to the lack of regeneration in the mammalian CNS after injury (4).

Bioinformatics

Entrez	17136 Mouse 29409 Rat 4099 Human
Uniprot	NP_002352 Human NP_002352.1 Human P20916 Human
Product By Gene ID	4099
Alternate Names	GMAsialic acid binding Ig-like lectin 4A myelin associated glycoprotein myelin-associated glycoprotein sialic acid-binding immunoglobulin-like lectin 4A SIGLEC4A Siglec-4a SIGLEC-4A S-MAG