Hu, Mu, Mouse, RatApplications:
Applications: WB, Neut
Host: Mouse Monoclonal
WB, ELISA, PA
Applications: WB, ELISA, PA
Applications: B/N, Ctrl
Myelin-associated glycoprotein (MAG), a membrane glycoprotein of 100 kDa, is thought to be involved in the process of myelination (1). Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in myelin, Nogo and MAG (2). MAG has been implicated in inhibition of nerve regeneration in the CNS. This results from interactions between MAG and the Nogo receptor and gangliosides on the apposing axon, which generates intracellular inhibitory signals in the neuron (3). Results also suggest that MAG binds to a specific receptor and initiates a signal transduction cascade to effect inhibition. These results indicate that soluble dMAG detected in vivo could contribute to the lack of regeneration in the mammalian CNS after injury (4).
|Product By Gene ID
- sialic acid-binding immunoglobulin-like lectin 4A
- GMAsialic acid binding Ig-like lectin 4A
- myelin-associated glycoprotein
- myelin associated glycoprotein
Bioinformatics Tool for MAG/Siglec-4a
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