MAD2L1 Products

Antibodies
MAD2L1 Antibody
MAD2L1 Antibody
NB100-563
Species: Hu, Bovine, Ferret, Guinea Pig, Primate, Porcine, Rat, Rhesus Macaque
Applications: ICC/IF, IHC, IHC-P, IP, WB (-)
Host: Rabbit Polyclonal
MAD2L1 Antibody
MAD2L1 Antibody
NBP1-31311
Species: Hu, Rt, Bovine, Rhesus Macaque
Applications: WB, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
MAD2L1 Antibody [Unconjugated ...
MAD2L1 Antibody [Unconjugated]
AF4005
Species: Hu, Rt
Applications: WB, ICC
Host: Goat Polyclonal
Lysates
MAD2L1 Overexpression Lysate ...
MAD2L1 Overexpression Lysate (Native)
NBL1-12786
Applications: WB
Proteins
MAD2L1 Recombinant Protein An ...
MAD2L1 Recombinant Protein Antigen
NBP1-83185PEP
Species: Hu
Applications: AC
MAD2L1 Peptide
MAD2L1 Peptide
NBP1-96765
Applications: WB, ELISA, IP
MAD2L1 Recombinant Protein
MAD2L1 Recombinant Protein
NBP1-72458
Species: Hu
Applications: PAGE
RNAi
MAD2L1 RNAi
MAD2L1 RNAi
H00004085-R01
Species: Hu

Description

The spindle checkpoint ensures the fidelity of chromosome segregation in mitosis and meiosis. In response to defects in the mitotic apparatus, it blocks the activity of the anaphase-promoting complex, a large ubiquitin ligase required for chromosome segregation. Recent studies indicate that the spindle checkpoint monitors both the attachment of chromosomes to the mitotic spindle and the tension across the sister chromatid generated by microtubules. Upon checkpoint activation, checkpoint protein complexes containing BubR1(Mad3), Bub3, Mad2 and Cdc20 directly bind to the anaphase-promoting complex and inhibit its ligase activity. Therefore, the checkpoint proteins form a complex intracellular signalling network to inhibit the anaphase-promoting complex.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 4085
Alternate Names
  • Mitotic arrest deficient 2-like protein 1
  • HsMAD2
  • MAD2 (mitotic arrest deficient, yeast, homolog)-like 1
  • mitotic spindle assembly checkpoint protein MAD2A
  • HSMAD2
  • MAD2mitotic arrest deficient, yeast, homolog-like 1
  • MAD2-like protein 1
  • MAD2 mitotic arrest deficient-like 1 (yeast)

Research Areas for MAD2L1

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Cell Cycle and Replication
Core ESC-Like Genes
DNA Repair
Stem Cell Markers

Bioinformatics Tool for MAD2L1

Discover related pathways, diseases and genes to MAD2L1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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