MAD2L1 Products

Description

The spindle checkpoint ensures the fidelity of chromosome segregation in mitosis and meiosis. In response to defects in the mitotic apparatus, it blocks the activity of the anaphase-promoting complex, a large ubiquitin ligase required for chromosome segregation. Recent studies indicate that the spindle checkpoint monitors both the attachment of chromosomes to the mitotic spindle and the tension across the sister chromatid generated by microtubules. Upon checkpoint activation, checkpoint protein complexes containing BubR1(Mad3), Bub3, Mad2 and Cdc20 directly bind to the anaphase-promoting complex and inhibit its ligase activity. Therefore, the checkpoint proteins form a complex intracellular signalling network to inhibit the anaphase-promoting complex.

Bioinformatics

Entrez	4085 Human 56150 Mouse
Uniprot	AAH00356 Human NM_002358 Human NP_002349 Human NP_002349. Human NP_002349.1 Human Q13257 Human
Product By Gene ID	4085
Alternate Names	HsMAD2 HSMAD2 MAD2 (mitotic arrest deficient, yeast, homolog)-like 1 MAD2 mitotic arrest deficient-like 1 (yeast) MAD2-like protein 1 MAD2mitotic arrest deficient, yeast, homolog-like 1 Mitotic arrest deficient 2-like protein 1 mitotic spindle assembly checkpoint protein MAD2A

Research Areas for MAD2L1

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Cell Cycle and Replication
Core ESC-Like Genes
DNA Repair
Stem Cell Markers