LOX Products

Antibodies
Lysates
LOX Overexpression Lysate
LOX Overexpression Lysate
NBL1-12640
Species: Hu
Applications: WB
Proteins
Recombinant Human LOX Protein ...
Recombinant Human LOX Protein
NBP2-59887
Species: Hu
Applications: PAGE
LOX Antibody Blocking Peptide ...
LOX Antibody Blocking Peptide
NB100-2530PEP
Species: Hu
Applications: AC
LOX Antibody Blocking Peptide ...
LOX Antibody Blocking Peptide
NB100-2527PEP
Species: Hu
Applications: AC

Description

Lysyl oxidase (LOX), a copper-containing amine oxidase, belongs to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes. LOX plays a vital role in the formation and repair of the extracellular matrix. In addition, LOX is a multifunctional enzyme having diverse biological functions such as developmental regulation, tumor suppression, cell motility, and cellular senescence. The secreted form of LOX is responsible for the invasive properties of hypoxic human cancer cells. Thus, Lysyl oxidase is essential for hypoxia-induced metastasis and is a good therapeutic target for preventing and treating metastases.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Rat
Product By Gene ID 4015
Alternate Names
  • protein-lysine 6-oxidase
  • MGC105112
  • lysyl oxidaseEC 1.4.3.13

Research Areas for LOX

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cytoskeleton Markers
Endothelial Cell Markers
Extracellular Matrix
Hypoxia
Signal Transduction

Bioinformatics Tool for LOX

Discover related pathways, diseases and genes to LOX. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related LOX Blog Posts

Check out the latest blog posts on LOX.
LOX: A prime enzyme
LOX is a copper-dependent amine oxidase enzyme that executes post-translational oxidative deamination on peptidyl lysine residues in precursors of fibrous collagen and elastin. LOX is secreted into the extracellular environment in an inactive form, wh...    Read more.
Understanding DNA Recombination with Cre-Lox
Cyclization recombination enzyme (Cre) is a member of the extensive family of recombinases and recognizes a 34 bp sequence motif from PI bacteriophage referred to as LoxP. The Cre enzyme works to cleanly excise an intervening DNA fragment that is flan...    Read more.
Cre/Lox: The Genomic Utility Knife
Cre (Cyclization recombination enzyme) is a member of the large family of recombinases. Cre recognizes Lox site loxP, a 34 bp sequence motif from the PI bateriophage. If a DNA segment is flanked by two loxP sites in the same orientation, Cre neatly ex...    Read more.
LOX propeptide: A novel peptide cancer therapeutic
Lysyl oxidase, also known as LOX, is a copper-dependent enzyme that cross-links collagen and elastin through the oxidative deamination of peptidyl lysine (collagen and elastin) and hydroxylysine (collagen only) residues, thereby playing a critical rol...    Read more.
Read more LOX related blogs.