LITAF Products

Description

Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]

Bioinformatics

Entrez	9516 Human
Uniprot	NM_004862 Human NP_001129944 Human NP_004853 Human NP_004853 Human NP_004853.2 Human
Product By Gene ID	9516
Alternate Names	CMT1C FLJ38636 lipopolysaccharide-induced TNF factor lipopolysaccharide-induced TNF-alpha factor lipopolysaccharide-induced tumor necrosis factor-alpha factor LPS-induced TNF-alpha factor MGC116698 MGC116700 MGC125275 MGC125276 p53-induced gene 7 protein PIG7MGC116701 SIMPLEMGC125274 Small integral membrane protein of lysosome/late endosome TP53I7 tumor protein p53 inducible protein 7

Research Areas for LITAF

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Signal Transduction