LIM kinase 2 Products

Description

LIM-kinase 2 (LIMK2), a 75-kDa member of the LIM kinase family, is responsible for regulating actin polymerization via phosphorylation and inactivation of the actin depolymerizing factors ADF/cofilin (1). LIMK2 protein is found in the cytoplasm during interphase, redistributed to the mitotic spindle and then to the spindle midzone during anaphase to telophase (2). It has been shown that ROCK, a downstream protein kinase of Rho, activates LIMK2 by directly phosphorylates threonine 505 residue. Since activity of LIMK2 is cell cycle dependant, LIMK2 activity is markedly increased when HeLa cells are synchronized at mitosis with nocodazole treatment (3).

Bioinformatics

Entrez	3985 Human 16886 Mouse 29524 Rat
Uniprot	NP_005560 Human AAH13051 Human AAH13051.1 Human NM_001031801 Human NP_057952 Human NP_001026971.1 Human P53667 Human P53671 Human Q99464 Human
Product By Gene ID	3985
Alternate Names	EC 2.7.11.1 LIMK-2 LIM domain kinase 2

Diseases related to LIM kinase 2

Discover more about diseases related to LIM kinase 2.

Malignant Neoplasms
Neoplasms
Tissue Adhesions
Neoplasm Metastasis
Cell Invasion
Carcinoma
Nervousness
Cell Transformation, Neoplastic
Neurofibromatoses
Prostatic Neoplasms
Malignant Neoplasm Of Breast
Mammary Neoplasms
Hereditary Diseases
Neurofibromatosis 1
Malignant Paraganglionic Neoplasm
Hypertrophy
Diabetes Mellitus, Experimental
Williams Syndrome
Tumor Progression
Neuroblastoma

Pathways for LIM kinase 2

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Localization
Cell Cycle
Spermatogenesis
Cell Proliferation
Mitosis
Cell Migration
Actin Cytoskeleton Reorganization
Cell Death
Rna Interference
Cell Adhesion
Interphase
Meiosis
Tight Junction Assembly
Cell Motility
Oncogenesis
Telophase
Anaphase
Cell Cycle Arrest
Prophase
Nuclear Import

Research Areas for LIM kinase 2

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Breast Cancer
Cancer
Phospho-Specific
Protein Kinase

PTMs for LIM kinase 2

Learn more about PTMs related to LIM kinase 2.

Phosphorylation
Dephosphorylation
Cleavage
Acetylation

Bioinformatics Tool for LIM kinase 2

Discover related pathways, diseases and genes to LIM kinase 2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.