WB, ICC/IF, IHC, IHC-PHost:
Species: Hu, Mu
Applications: WB, ELISA, Flow, ICC/IF, IHC
Host: Mouse Monoclonal
WB, ELISA, ICC/IF, IHC-PHost:
Applications: WB, ELISA, PA
Applications: RNAi, RNAi SP
Ku80, also known as XRCC5, plays a role in many diverse processes including cell signaling, proliferation, DNA repair, replication, transcriptional activation and apoptosis.
As one half of the heterodimer complex Ku, Ku80 is required for proper maintenance of the telomeric C strand. Ku80 also plays a role in DNA repair as an essential subunit of DNA-dependent protein kinase (DNA-PK) that phosphorylates certain transcription factors (Sp1, Oct-1 and p53). The heterodimer Ku binds double stranded DNA breaks for non-homologous end joining repair. Ku mutants are defective in T-DNA integration and over-expression confers increased resistance to DNA damage agents and increased susceptibility to T-DNA transformation.
|Product By Gene ID
- ATP-dependent DNA helicase II 80 kDa subunit
- ATP-dependent DNA helicase 2 subunit 2
- EC 3.6.4.-
- X-ray repair, complementing defective, repair in Chinese hamster
- X-ray repair cross-complementing protein 5
- Ku86 autoantigen related protein 1,86 kDa subunit of Ku antigen
- Thyroid-lupus autoantigen
- X-ray repair complementing defective repair in Chinese hamster cells 5(double-strand-break rejoining; Ku autoantigen, 80kD)
- Ku86DNA repair protein XRCC5
- X-ray repair complementing defective repair in Chinese hamster cells 5(double-strand-break rejoining)CTC box-binding factor 85 kDa subunit
Bioinformatics Tool for Ku80/XRCC5
Discover related pathways, diseases and genes to Ku80/XRCC5. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.