KLF15 Products

Description

The kidney chloride channel proteins CLCNKA and CLCNKB are highly related, although they are located in different areas of the kidney. Using a yeast 1-hybrid screen of a kidney cDNA library with the GA element of the CLCNKA promoter as bait, Uchida et al. (2000) isolated cDNAs encoding MAZ and KLF15, which they termed KKLF. Sequence analysis predicted that the 415-amino acid KLF15 protein, which is 84% identical to the rat Klf15 protein, contains 3 zinc finger motifs at its C terminus, N-terminal serine-rich stretches, and a central proline-rich segment. EMSA analysis confirmed that KLF15 and MAZ interact with the GA element of the CLCNKA promoter and showed that KLF15 binds with higher affinity and is a functional competitor of MAZ. Northern blot analysis revealed highest expression of a 2.5-kb KLF15 transcript in liver, followed by heart, skeletal muscle, and kidney. No expression was found in bone marrow or lymphoid tissues. Western blot analysis showed expression of a 50-kD protein. Immunohistochemical analysis detected nuclear expression of KLF15 in liver sinusoid stellate cells, subcapsular fibroblasts, and portal fibroblasts. KLF15 was also expressed in cardiac and skeletal muscle interstitial cells and in kidney inner medulla, glomeruli, and cortical interstitium. Immunofluorescence microscopy, however, demonstrated no colocalization of KLF15 with CLCNKA.

Bioinformatics

Entrez	28999 Human 66277 Mouse 85497 Rat
Uniprot	Q9UIH9 Human NM_014079 Human NP_054798 Human NP_054798. Human NP_054798.1 Human
Product By Gene ID	28999
Alternate Names	Krueppel-like factor 15 kidney-enriched Kruppel-like factor DKFZp779M1320 KKLFKidney-enriched krueppel-like factor Kruppel-like factor 15

Diseases related to KLF15

Discover more about diseases related to KLF15.

Hypertrophy
Obesity
Heart Failure
Insulin Resistance
Diabetes Mellitus
Cardiac Hypertrophy
Fibrosis
Inflammation
Kidney Diseases
Facial Paralysis
Malignant Neoplasms
Chronic Kidney Disease
Mammary Neoplasms
Diabetes Mellitus, Non-insulin-dependent
Glomerulosclerosis (disorder)
Stenosis
Left Ventricular Hypertrophy
Hyperglycemia
Proteinuria Of Undiagnosed Cause

Pathways for KLF15

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Transport
Localization
Gluconeogenesis
Glucose Transport
Glucose Homeostasis
Cell Cycle
Cell Differentiation
Cell Proliferation
Energy Homeostasis
Dna Replication
Regulation Of Gluconeogenesis
Cell Growth
Pathogenesis
Hyperphosphorylation
Brain Development
Aging
Neurogenesis
Regulation Of Gene Expression
Oxidative Phosphorylation
Chondrocyte Hypertrophy

PTMs for KLF15

Learn more about PTMs related to KLF15.

Phosphorylation
Acetylation
Oxidation
Deacetylation
Methylation

Bioinformatics Tool for KLF15

Discover related pathways, diseases and genes to KLF15. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.