KLF15 Products

Antibodies
KLF15 Antibody
KLF15 Antibody
NBP2-24635
Species: Hu, Bovine, Mouse, Porcine, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
KLF15 Antibody (1F3)
KLF15 Antibody (1F3)
H00028999-M02
Species: Hu
Applications: WB, ELISA, IP
Host: Mouse Monoclonal
KLF15 Antibody
KLF15 Antibody
H00028999-B01P
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Polyclonal
Antibody Pairs
KLF15 Antibody Pair
KLF15 Antibody Pair
H00028999-PW1
Species: Hu
Applications: WB, IP
Lysates
KLF15 Overexpression Lysate ( ...
KLF15 Overexpression Lysate (Denat...
H00028999-T01
Species: Hu
Applications: WB
KLF15 Overexpression Lysate ( ...
KLF15 Overexpression Lysate (Native)
NBL1-12317
Applications: WB
Proteins
KLF15 Partial Recombinant Pro ...
KLF15 Partial Recombinant Protein
H00028999-Q01
Species: Hu
Applications: WB, ELISA, PA
KLF15 Recombinant Protein
KLF15 Recombinant Protein
H00028999-P01
Species: Hu
Applications: WB, ELISA, PA
KLF15 Recombinant Protein Ant ...
KLF15 Recombinant Protein Antigen
NBP1-82872PEP
Species: Hu
Applications: AC
RNAi
KLF15 RNAi
KLF15 RNAi
H00028999-R01
Species: Hu

Description

The kidney chloride channel proteins CLCNKA and CLCNKB are highly related, although they are located in different areas of the kidney. Using a yeast 1-hybrid screen of a kidney cDNA library with the GA element of the CLCNKA promoter as bait, Uchida et al. (2000) isolated cDNAs encoding MAZ and KLF15, which they termed KKLF. Sequence analysis predicted that the 415-amino acid KLF15 protein, which is 84% identical to the rat Klf15 protein, contains 3 zinc finger motifs at its C terminus, N-terminal serine-rich stretches, and a central proline-rich segment. EMSA analysis confirmed that KLF15 and MAZ interact with the GA element of the CLCNKA promoter and showed that KLF15 binds with higher affinity and is a functional competitor of MAZ. Northern blot analysis revealed highest expression of a 2.5-kb KLF15 transcript in liver, followed by heart, skeletal muscle, and kidney. No expression was found in bone marrow or lymphoid tissues. Western blot analysis showed expression of a 50-kD protein. Immunohistochemical analysis detected nuclear expression of KLF15 in liver sinusoid stellate cells, subcapsular fibroblasts, and portal fibroblasts. KLF15 was also expressed in cardiac and skeletal muscle interstitial cells and in kidney inner medulla, glomeruli, and cortical interstitium. Immunofluorescence microscopy, however, demonstrated no colocalization of KLF15 with CLCNKA.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 28999
Alternate Names
  • Krueppel-like factor 15
  • kidney-enriched Kruppel-like factor
  • DKFZp779M1320
  • KKLFKidney-enriched krueppel-like factor
  • Kruppel-like factor 15

PTMs for KLF15

Learn more about PTMs related to KLF15.

Phosphorylation
Acetylation
Oxidation
Deacetylation
Methylation

Bioinformatics Tool for KLF15

Discover related pathways, diseases and genes to KLF15. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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