KLF15 Products

Antibodies
KLF15 Antibody - BSA Free
KLF15 Antibody - BSA Free
NBP2-24635
Species: Hu, Mu, Rt, Bv, Po
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Formulation Catalog # Availability Price  
KLF15 Antibody - BSA Free
KLF15 Antibody - BSA Free
NBP2-84120
Species: Hu
Applications: WB, IHC
Host: Rabbit Polyclonal
Formulation Catalog # Availability Price  
KLF15 Antibody - BSA Free
KLF15 Antibody - BSA Free
NBP2-84119
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Formulation Catalog # Availability Price  
ELISA Kits
Human KLF15 - Ready-To-Use E ...
Human KLF15 - Ready-To-Use ELISA ...
NBP3-39721
Species: Hu
Applications: ELISA
Human KLF15 ELISA Kit (Colori ...
Human KLF15 ELISA Kit (Colorimetric)
NBP3-39720
Species: Hu
Applications: ELISA
Lysates
KLF15 Overexpression Lysate
KLF15 Overexpression Lysate
NBL1-12317
Species: Hu
Applications: WB
Proteins
KLF15 Antibody Blocking Pepti ...
KLF15 Antibody Blocking Peptide
NBP2-24635PEP
Applications: AC
Recombinant Human KLF15 GST ( ...
Recombinant Human KLF15 GST (N-Ter...
H00028999-Q01
Species: Hu
Applications: WB, ELISA, MA, PAGE, AP
Recombinant Human KLF15 GST ( ...
Recombinant Human KLF15 GST (N-Ter...
H00028999-P01
Species: Hu
Applications: WB, ELISA, MA, AP

Description

The kidney chloride channel proteins CLCNKA and CLCNKB are highly related, although they are located in different areas of the kidney. Using a yeast 1-hybrid screen of a kidney cDNA library with the GA element of the CLCNKA promoter as bait, Uchida et al. (2000) isolated cDNAs encoding MAZ and KLF15, which they termed KKLF. Sequence analysis predicted that the 415-amino acid KLF15 protein, which is 84% identical to the rat Klf15 protein, contains 3 zinc finger motifs at its C terminus, N-terminal serine-rich stretches, and a central proline-rich segment. EMSA analysis confirmed that KLF15 and MAZ interact with the GA element of the CLCNKA promoter and showed that KLF15 binds with higher affinity and is a functional competitor of MAZ. Northern blot analysis revealed highest expression of a 2.5-kb KLF15 transcript in liver, followed by heart, skeletal muscle, and kidney. No expression was found in bone marrow or lymphoid tissues. Western blot analysis showed expression of a 50-kD protein. Immunohistochemical analysis detected nuclear expression of KLF15 in liver sinusoid stellate cells, subcapsular fibroblasts, and portal fibroblasts. KLF15 was also expressed in cardiac and skeletal muscle interstitial cells and in kidney inner medulla, glomeruli, and cortical interstitium. Immunofluorescence microscopy, however, demonstrated no colocalization of KLF15 with CLCNKA.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 28999
Alternate Names
  • DKFZp779M1320
  • kidney-enriched Kruppel-like factor
  • KKLFKidney-enriched krueppel-like factor
  • Krueppel-like factor 15
  • Kruppel-like factor 15