Ki67/MKI67 Products

Antibodies
ELISA Kits
Human Ki67/MKI67 DuoSet ELISA ...
Human Ki67/MKI67 DuoSet ELISA, 5 P...
DY7617-05
Species: Hu
Applications: ELISA
Proteins
Recombinant Human Ki67/MKI67 ...
Recombinant Human Ki67/MKI67 Protein
H00004288-Q01
Species: Hu
Applications: WB, ELISA, PA, AP
Ki67/MKI67 Recombinant Protei ...
Ki67/MKI67 Recombinant Protein Ant...
NBP2-54656PEP
Species: Hu
Applications: AC

Description

Ki67 is a nuclear protein associated with proliferation, named after its discovery in a Hodgkin's lymphoma-derived cell line by Scholzer and Gerdes at Kiel University, Germany (1). This proliferation marker is expressed during active phases of the cell cycle (late G1, S, G2 and M), whereas the protein remains undetectable in the G0 phase. Ki67 has two main isoforms with theoretical molecular weights of 319 kDa and 359 kDa. Its abundance is tightly regulated by synthesis and degradation with an estimated half-life of 60-90 min, regardless of its position in the cell cycle. Ki67 has been shown to be involved in ribosomal biogenesis, heterochromatin maintenance, and mitotic chromosome separation (2).

Detection of Ki67 by immunostaining is commonly used as a proliferation marker in solid tumors, as well as certain hematological malignancies (3-5). The Ki67 index, which reports on positive Ki67 stained tumor cell nuclei, has been extensively studied as a prognostic biomarker in cancers such as breast cancer and cervical cancer.

References

1. Gerdes J, Schwab U, Lemke H, Stein H. (1983) Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer. 31:13-20. PMID: 6339421

2. Starborg M, Gell K, Brundell E and Hoog C. (1996) The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progression. J Cell Sci. 109:143-153. 1996

3. Karamitopoulou E, Perentes E, Tolnay M, Probst A. (1998) Prognostic significance of MIB-1, p53, and bcl-2 immunoreactivity in meningiomas. Hum Pathol. 29(2):140-5. PMID: 9490273

4. Geyer FC, Rodrigues DN, Weigelt B and Reis-Filho JS. (2012) Molecular classification of estrogen receptor-positive/luminal breast cancers. Adv Anat Pathol. 19(1):39-53. PMID: 22156833

5. Ikenberg H, Bergeron C, Schmidt D, Griesser H, Alameda F, Angeloni C, Bogers J, Dachez R, Denton K, Hariri J, Keller T, von Knebel Doeberitz M, Neumann HH, Puig-Tintore LM, Sideri M, Rehm S, Ridder R; PALMS Study Group. (2013) Screening for cervical cancer precursors with p16/Ki-67 dual-stained cytology: results of the PALMS study. J Natl Cancer Inst. 105(20):1550-7. PMID: 24096620



Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Mouse
Mouse
Product By Gene ID 4288
Alternate Names
  • Proliferation Marker Protein Ki-67
  • Antigen Ki67
  • MIB-
  • Ki67
  • Ki-67
  • MIB-1
  • PPP1R105
  • Marker Of Proliferation Ki-67
  • Protein Phosphatase 1
  • Regulatory Subunit 105
  • proliferation-related Ki-67 antigen
  • antigen KI-67
  • KIA
  • antigen identified by monoclonal Ki-67

Research Areas for Ki67/MKI67

Find related products by research area and learn more about each of the different research areas below.

Cell Biology
Cell Cycle and Replication
Cellular Markers
Growth and Development
Neuronal Cell Markers
Neuronal Stem Cell Markers
Neuroscience
Stem Cell Markers

PTMs for Ki67/MKI67

Learn more about PTMs related to Ki67/MKI67.

Phosphorylation
Methylation
Cleavage
Ribosylation
Myristoylation

Bioinformatics Tool for Ki67/MKI67

Discover related pathways, diseases and genes to Ki67/MKI67. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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Related Ki67/MKI67 Blog Posts

Check out the latest blog posts on Ki67/MKI67.
The relationship between Ki67 and HIF-1 in cancer
Ki67, also known as MKI67, is best known as the leading marker of cellular proliferation. Ki67 is regulated by a balance between synthesis and degradation, and often carries a very short half-life.  First discovered to be located to dividing cells,...    Read more.
Ki67 - an established marker for labelling proliferating cells
Ki-67/MKI67 is an antigen which is expressed during G1, S, G2, and M phases of the cell cycle (mitotically active cells), but not during G0 phase (resting cells). It is a large protein with expected molecular weight of about 395 kDa, and it has a v...    Read more.
Ki67 - A Crucial Cellular Proliferation Marker
The Ki67 antigen is a prototypic cell cycle-related protein expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M). It is a non-histone nuclear protein originally identified in a Hodgkin's lymphoma-derived cell line....    Read more.
The Ki67 Antibody in Cell Marker Studies
The MK167, or Ki67 antibody recognizes a nuclear protein encoded by the MK167 gene. Ki167 is involved with RNA transcription and essential to cellular proliferation, being expressed by proliferating cells at all stages of the active cell cycle; it is...    Read more.
Read more Ki67/MKI67 related blogs.