KDELR1 Products

Description

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. [provided by RefSeq]

Bioinformatics

Entrez	10945 Human
Uniprot	NM_006801 Human NP_006792.1 Human Q99JH8 Mouse
Product By Gene ID	10945
Alternate Names	ER lumen protein retaining receptor 1 ERD2 ERD2.1KDEL receptor 1 HDEL KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 KDEL endoplasmic reticulum protein retention receptor 1 PM23 Putative MAPK-activating protein PM23