KCNK1 Products

Description

K+ channels are divided into three subclasses, reflecting the number of transmembrane segments (TMS), which are designated 6TMS, 4TMS and 2TMS. Members of the 4TMS class contain two distinct pore regions, and include TASK, TREK, TRAAK and TWIK. TWIK-1 mRNA is expressed abundantly in brain and at lower levels in lung, kidney and skeletal muscle. The molecular weight of TWIK-1 in mouse brain is 40 kDa under reducing conditions. TWIK-2 shares low sequence homology with other mammalian family group members, and only 34% homology with TWIK-1. Human TWIK-2 is expressed in pancreas, placenta and heart, while mouse TWIK-2 is expressed in liver. TWIK-2 is inhibited by intracellular, but not extracellular, acidification.

Bioinformatics

Entrez	3775 Human 59324 Rat
Uniprot	O00180 Human NP_002236.1 Human NM_002245 Human
Product By Gene ID	3775
Alternate Names	Potassium channel KCNO1 HOHO1 Inward rectifying potassium channel protein TWIK-1 potassium inwardly-rectifying channel, subfamily K, member 1 TWIK-1 potassium channel subfamily K member 1 K2p1.1 K2P1 DPK TWIK1HOHO KCNO1 potassium channel, subfamily K, member 1

Diseases related to KCNK1

Discover more about diseases related to KCNK1.

Cardiac Arrhythmia
Fibrosis
Adenoma
Neoplasms
Adrenal Gland Neoplasms
Malignant Paraganglionic Neoplasm
Diabetes Mellitus
Hyperaldosteronism
Neonatal Abstinence Syndrome
Cystic Fibrosis
Nervousness
Atherosclerosis
Melanoma
Glioma
Chronic Periodontitis
Malignant Neoplasms
Sudden Death
Chimera Disorder
Calcification Of Coronary Artery
Tobacco Use Disorder

Pathways for KCNK1

View related products by pathway and learn more about each of the pathways below.

Localization
Transport
Secretion
Chromosome Localization
Ion Transport
Glycosylation
Endocytosis
Conjugation
Cell Cycle Arrest
Neuroprotection
Membrane Depolarization
Reverse Transcription
Sensitization
Cellular Localization
Cell Cycle
Water Transport
Cell Growth
Response To Nicotine

PTMs for KCNK1

Learn more about PTMs related to KCNK1.

Sumoylation
Phosphorylation
Glycosylation

Bioinformatics Tool for KCNK1

Discover related pathways, diseases and genes to KCNK1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.