KCNJ1 Products

Antibodies
KCNJ1 Antibody
KCNJ1 Antibody
NBP1-82874
Species: Hu, Mouse, Rat
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
KCNJ1 Antibody
KCNJ1 Antibody
NBP1-36965
Species: Hu
Applications: WB, PEP-ELISA
Host: Goat Polyclonal
KCNJ1 Antibody
KCNJ1 Antibody
NBP1-30792
Species: Hu
Applications: WB, IHC, IHC-Fr, IHC-P
Host: Rabbit Polyclonal
Lysates
KCNJ1 Overexpression Lysate ( ...
KCNJ1 Overexpression Lysate (Native)
NBL1-12162
Applications: WB
Proteins
KCNJ1 Partial Recombinant Pro ...
KCNJ1 Partial Recombinant Protein
H00003758-Q01
Species: Hu
Applications: WB, ELISA, PA
KCNJ1 Recombinant Protein
KCNJ1 Recombinant Protein
H00003758-P01
Species: Hu
Applications: WB, ELISA, PA
KCNJ1 Recombinant Protein Ant ...
KCNJ1 Recombinant Protein Antigen
NBP1-82874PEP
Species: Hu
Applications: AC
RNAi
KCNJ1 RNAi
KCNJ1 RNAi
H00003758-R01
Species: Hu
KCNJ1 RNAi
KCNJ1 RNAi
H00003758-R04
Species: Hu
KCNJ1 RNAi
KCNJ1 RNAi
H00003758-R05
Species: Hu

Description

FUNCTION: In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.; Tissue specificity: In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver.; Subcellular location: Membrane, Multi-pass membrane protein.; Involvement in disease: Defects in KCNJ1 are the cause of Bartter syndrome type 2 (BS2) also termed hyperprostanglandin E syndrome 2. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS2 is a life-threatening condition beginning in utero, with marked fetal polyuria that leads to polyhydramnios and premature delivery. Another hallmark of BS2 is a marked hypercalciuria and, as a secondary consequence, the development of nephrocalcinosis and osteopenia.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 3758
Alternate Names
  • Kir1.1
  • inwardly rectifying K+ channel
  • ATP-regulated potassium channel ROM-K
  • ATP-sensitive inward rectifier potassium channel 1
  • ROMK1inwardly rectifying subfamily J member 1
  • KIR1.1
  • potassium inwardly-rectifying channel, subfamily J, member 1

PTMs for KCNJ1

Learn more about PTMs related to KCNJ1.

Phosphorylation
Glycosylation
Dephosphorylation
Biotinylation
Cleavage
Ubiquitination

Bioinformatics Tool for KCNJ1

Discover related pathways, diseases and genes to KCNJ1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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