JIP2 Products

Antibodies
JIP2 Antibody
JIP2 Antibody
NBP1-31411
Species: Hu, Mu
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
JIP2 Antibody
JIP2 Antibody
NBP1-89638
Species: Hu, Mu, Rt
Applications: IHC
Host: Rabbit Polyclonal
JIP2 Antibody
JIP2 Antibody
NBP1-33035
Species: Hu, Mu
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Proteins
Recombinant Human JIP2 GST (N ...
Recombinant Human JIP2 GST (N-Term...
H00023542-Q01
Species: Hu
Applications: WB, ELISA, MA, AP
Recombinant Human JIP2 GST (N ...
Recombinant Human JIP2 GST (N-Term...
H00023542-P01
Species: Hu
Applications: WB, ELISA, MA, AP
Recombinant Human JIP2 GST (N ...
Recombinant Human JIP2 GST (N-Term...
H00023542-P02
Species: Hu
Applications: WB, ELISA, MA, PAGE, AP

Description

c-Jun NH2-terminal kinases (JNKs) are distant members of the MAP kinase family. JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to ultraviolet (UV) light, and it functions to phosphorylate c-Jun at amino terminal serine regulatory sites, Ser 63 and Ser 73, resulting in transcriptional activation. Two additional JNK family members have been identified as JNK2 and JNK3. JIP-1 (for JNK interacting protein-1) has been identified as a cytoplasmic inhibitor of JNK that retains JNK in the cytoplasm, thereby inhibiting JNK-regulated gene expression. Evidence suggests that JNK1 and JNK2 bind to JIP-1 with greater affinity than to ATF-2 and c-Jun, which are targets of the JNK signaling pathway. JIP-1 contains an amino terminal JNK binding domain and a carboxy terminal SH3 domain. ATF-2 and c-Jun also contain the JNK binding domain and are thought to compete with JIP-1 for JNK binding. Multiple splice variants of JIP-1, including JIP-1b, JIP-1c (also designated islet-brain 1 or IB-1), JIP-2a, JIP-2b and JIP-3, have been identified in brain.

Bioinformatics

Entrez Rat
Human
Mouse
Uniprot Human
Human
Human
Human
Human
Alternate Names
  • C-Jun-amino-terminal kinase-interacting protein 2
  • homologous to mouse JIP-1
  • IB-2
  • IB2JIP2Mitogen-activated protein kinase 8-interacting protein 2
  • islet-brain 2
  • islet-brain-2
  • Islet-brain-2
  • JIP-2
  • JNK MAP kinase scaffold protein 2
  • JNK MAP kinase scaffold protein JIP2
  • JNK-interacting protein 2
  • mitogen-activated protein kinase 8 interacting protein 2
  • PRKM8 interacting protein-like
  • PRKM8IPL

Research Areas for JIP2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis