JIP2 Products

Antibodies
JIP2 Antibody
JIP2 Antibody
NB100-92373
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
JIP2 Antibody
JIP2 Antibody
NBP1-33035
Species: Hu, Mu
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
JIP2 Antibody
JIP2 Antibody
NBP1-31411
Species: Hu, Mu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
JIP2 Overexpression Lysate (N ...
JIP2 Overexpression Lysate (Native)
NBP2-10465
Applications: WB
Proteins
JIP2 Partial Recombinant Prot ...
JIP2 Partial Recombinant Protein
H00023542-Q01
Species: Hu
Applications: WB, ELISA, PA
JIP2 Recombinant Protein
JIP2 Recombinant Protein
H00023542-P01
Species: Hu
Applications: WB, ELISA, PA
JIP2 Recombinant Protein Anti ...
JIP2 Recombinant Protein Antigen
NBP1-89638PEP
Species: Hu
Applications: AC

Description

c-Jun NH2-terminal kinases (JNKs) are distant members of the MAP kinase family. JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to ultraviolet (UV) light, and it functions to phosphorylate c-Jun at amino terminal serine regulatory sites, Ser 63 and Ser 73, resulting in transcriptional activation. Two additional JNK family members have been identified as JNK2 and JNK3. JIP-1 (for JNK interacting protein-1) has been identified as a cytoplasmic inhibitor of JNK that retains JNK in the cytoplasm, thereby inhibiting JNK-regulated gene expression. Evidence suggests that JNK1 and JNK2 bind to JIP-1 with greater affinity than to ATF-2 and c-Jun, which are targets of the JNK signaling pathway. JIP-1 contains an amino terminal JNK binding domain and a carboxy terminal SH3 domain. ATF-2 and c-Jun also contain the JNK binding domain and are thought to compete with JIP-1 for JNK binding. Multiple splice variants of JIP-1, including JIP-1b, JIP-1c (also designated islet-brain 1 or IB-1), JIP-2a, JIP-2b and JIP-3, have been identified in brain.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 23542
Alternate Names
  • Islet-brain-2
  • JNK-interacting protein 2
  • JNK MAP kinase scaffold protein JIP2
  • JNK MAP kinase scaffold protein 2
  • islet-brain-2
  • PRKM8IPL
  • islet-brain 2
  • JIP-2
  • homologous to mouse JIP-1
  • IB-2
  • C-Jun-amino-terminal kinase-interacting protein 2
  • IB2JIP2Mitogen-activated protein kinase 8-interacting protein 2
  • PRKM8 interacting protein-like
  • mitogen-activated protein kinase 8 interacting protein 2

Research Areas for JIP2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis

PTMs for JIP2

Learn more about PTMs related to JIP2.

Phosphorylation
Cleavage
Dephosphorylation

Bioinformatics Tool for JIP2

Discover related pathways, diseases and genes to JIP2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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