ITPR2 Products

Description

Inositol 1,4,5-triphosphate (IP3) receptors are a form of ligand-gated ion channels that are activated by cytosolic Ca2+ and IP3. They are localized to intracellular membranes, such as the endoplasmic reticulum, and mediate the mobilization of intracellular Ca2+ stores. IP3 receptors play an important role in intracellular Ca2+ signaling in a variety of cell types. There are three IP3 receptor subtypes; IP3R1, IP3R2 and IP3R3, which exist as homo- and heterotetramers. All subtypes are closely associated with calmodulin and FK506-binding protein and are modulated through phosphorylation by PKA, PKC, PKG and CaMKII.

Bioinformatics

Entrez	16439 Mouse 3709 Human 81678 Rat
Uniprot	NP_002214.2 Human Q14571 Human
Product By Gene ID	3709
Alternate Names	inositol 14,5-triphosphate receptor, type 2 inositol 14,5-trisphosphate receptor type 2 InsP3R2 insP3R2 IP3 receptor isoform 2 IP3 receptor IP3R 2 IP3R2 Type 2 inositol 14,5-trisphosphate receptor Type 2 InsP3 receptor

Research Areas for ITPR2

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Neuroscience