Intersectin 1 Products

Description

Intersectin 1 is an adapter protein that may provide an indirect link between the endocytic membrane traffic and the actin assembly machinery. It may regulate the formation of clathrin-coated vesicles. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Intersectin 1 is overexpressed in brain from Down syndrome foetuses suggesting a gene dosage-dependent contribution to the abnormalities of Down syndrome. Intersectin 1 interacts with dynamin, CDC42, SNAP25 and SNAP23. It clusters several dynamin in a manner that is regulated by alternative splicing. Intersectin 1 also binds clathrin-associated proteins and other components of the endocytic machinery, such as SPIN90, EPS15, EPN1, EPN2 and STN2. Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Isoform 1 could be involved in brain-specific synaptic vesicle recycling.

Bioinformatics

Entrez	6453 Human
Uniprot	NP_003015 Human NP_003015.2 Human Q15811 Human
Product By Gene ID	6453
Alternate Names	11 intersectin 1 (SH3 domain protein) intersectin short variant 12 intersectin-1 ITSN SH3 domain protein-1A SH3 domain-containing protein 1A Src homology 3 domain-containing protein