Insulysin/IDE Products

Insulysin/IDE Antibody (JJ094 ...
Insulysin/IDE Antibody (JJ0949)
Species: Hu, Mu, Rt, Fi, Ze
Applications: WB, IHC, IHC-P
Host: Rabbit Monoclonal
Insulysin/IDE Antibody
Insulysin/IDE Antibody
Species: Hu
Applications: WB, IP
Host: Goat Polyclonal
Formulation Catalog # Availability Price  
Human Insulysin/IDE ELISA Kit ...
Human Insulysin/IDE ELISA Kit (Col...
Species: Hu
Applications: ELISA
Human Insulysin/IDE ELISA Kit ...
Human Insulysin/IDE ELISA Kit (Che...
Species: Hu
Applications: ELISA
Rat Insulysin/IDE ELISA Kit ( ...
Rat Insulysin/IDE ELISA Kit (Color...
Species: Rt
Applications: ELISA
Insulysin/IDE Overexpression ...
Insulysin/IDE Overexpression Lysate
Species: Hu
Applications: WB
Recombinant Human Insulysin/I ...
Recombinant Human Insulysin/IDE Pr...
Species: Hu
Applications: Enzyme Activity
Formulation Catalog # Availability Price  
Recombinant Rat Insulysin/IDE ...
Recombinant Rat Insulysin/IDE Prot...
Species: Rt
Applications: Enzyme Activity
Formulation Catalog # Availability Price  
Insulysin/IDE Recombinant Pro ...
Insulysin/IDE Recombinant Protein ...
Species: Hu
Applications: AC


Insulysin was identified nearly a century ago as an enzyme responsible for the degradation of insulin in cells, although the precise interactions between insulin and insulysin remain elusive. Human insulysin was cloned in 1988, and shown to be a 118 kDa protein that exists primarily as a homodimer, and perhaps also complexed with other molecules. The sequence is well conserved between humans, rats and mice, and the antibody recognizes these species. Insulysin is a metalloproteinase of the clan ME, family M16, which contains an active site HxxEH, a reversal of the canonical HExxH zinc binding motif. Considered a zinc metalloproteinase, the activity of insulysin can be blocked with EDTA or 1-10 phenanthroline. In addition to the active metalloproteinase domain, insulysin contains a second metalloproteinase site which is considered catalytically inactive, and is thought to assist in substrate binding. Insulysin is most closely related to the bacterial proteinase pitrilysin, (the human orthologue of which appears to be MPRP1) and the mammalian proteinsae nardilysin. Generally thought to be a cytoplasmic protein, insulysin has been isolated from many different tissues and cell lines, and can degrade intact insulin, insulin B chain, glucagon, denatured hemoglobin, alpha amyloid protein, TGF alpha and amylin. Recent work implicates insulysin in clearing beta amyloid plaques from the brain, and has generated much interest in Alzheimer's disease research. The pH optimum for insulysin is basic, pH 8.5, which also distinguishes it from other metalloproteinases. Insulin degrading enzyme (IDE) has a preferential affinity for insulin such that the presence of insulin will inhibit IDE mediated degradation of other substrates. IDE degrades a variety of other peptides including atrial natriuretic peptide and amylin. IDE catabolizes A beta and has been implicated as a candidate enzyme responsible for the degradation and clearance of A beta in the brain. IDE has also been shown to degrade the APP intracellular domain (AICD), a product of gamma secretase cleaved APP that may function in nuclear signaling.


Entrez Human
Uniprot Human
Product By Gene ID 3416
Alternate Names
  • EC 3.4.24
  • FLJ35968
  • Insulysin
  • EC
  • Insulinase
  • Abeta-degrading protease
  • insulinase
  • Insulin protease
  • insulin-degrading enzyme

Research Areas for Insulysin/IDE

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Lipid and Metabolism

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