INCA Products

Antibodies
INCA Antibody
INCA Antibody
NBP1-46144
Species: Hu
Applications: WB, PEP-ELISA
Host: Goat Polyclonal
INCA Antibody (1G6)
INCA Antibody (1G6)
H00440068-M01
Species: Hu
Applications: WB, ELISA
Host: Mouse Monoclonal
INCA Antibody
INCA Antibody
NBP1-74090
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Lysates
INCA Overexpression Lysate (D ...
INCA Overexpression Lysate (Denatu...
H00440068-T01
Species: Hu
Applications: WB
INCA Overexpression Lysate (N ...
INCA Overexpression Lysate (Native)
NBP2-10988
Applications: WB
Proteins
INCA Recombinant Protein
INCA Recombinant Protein
NBP2-22737
Species: Hu
Applications: PAGE

Description

INCA, also known as CAR17 or Caspase recruitment domain-containing protein 17, is a 110 amino acid protein that is 12 kDa; cytoplasm located; regulates procaspase-1/CASP1 activation involved in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation; and acts as an inhibitor of the release of IL1B in response to LPS in monocytes. Current research is being pursued on this protein involvement in several diseases and disorders including cancer, familial mediterranean fever, shigellosis, cowpox, neurodegenerative disease, vascular disease, mevalonic aciduria, tularemia, dermatitis, lung disease, legionnaires' disease, and arthritis. This protein has been linked to the proteolysis and regulation of apoptotic process pathways where it interacts with CASP1, CARD16, and CARD18 proteins.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 440068
Alternate Names
  • Inhibitory caspase recruitment domain protein
  • inhibitory caspase recruitment domain (CARD) protein
  • Caspase-1 inhibitor INCA
  • INCAInhibitory CARD
  • caspase recruitment domain-containing protein 17
  • caspase recruitment domain family, member 17

Research Areas for INCA

Find related products by research area and learn more about each of the different research areas below.

Apoptosis

Bioinformatics Tool for INCA

Discover related pathways, diseases and genes to INCA. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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