INCA Products

Description

INCA, also known as CAR17 or Caspase recruitment domain-containing protein 17, is a 110 amino acid protein that is 12 kDa; cytoplasm located; regulates procaspase-1/CASP1 activation involved in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation; and acts as an inhibitor of the release of IL1B in response to LPS in monocytes. Current research is being pursued on this protein involvement in several diseases and disorders including cancer, familial mediterranean fever, shigellosis, cowpox, neurodegenerative disease, vascular disease, mevalonic aciduria, tularemia, dermatitis, lung disease, legionnaires' disease, and arthritis. This protein has been linked to the proteolysis and regulation of apoptotic process pathways where it interacts with CASP1, CARD16, and CARD18 proteins.

Bioinformatics

Entrez	440068 Human
Uniprot	NP_001007233 Human NP_001007233.1 Human Q5XLA6 Human
Product By Gene ID	440068
Alternate Names	caspase recruitment domain family, member 17 caspase recruitment domain-containing protein 17 Caspase-1 inhibitor INCA INCAInhibitory CARD inhibitory caspase recruitment domain (CARD) protein Inhibitory caspase recruitment domain protein

Research Areas for INCA

Find related products by research area and learn more about each of the different research areas below.

Apoptosis