ILK Products

Antibodies
ILK Antibody (4F10)
ILK Antibody (4F10)
H00003611-M01
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, RNAi
Host: Mouse Monoclonal
ILK Antibody
ILK Antibody
NB100-809
Species: Hu, Mu, Rt, Po
Applications: WB, IHC, IHC-P, PEP-ELISA
Host: Goat Polyclonal
ILK Antibody (3A9)
ILK Antibody (3A9)
NBP2-37448
Species: Hu, Mu, Pm
Applications: WB, ELISA, Flow, IHC
Host: Mouse Monoclonal
Lysates
ILK Overexpression Lysate (Na ...
ILK Overexpression Lysate (Native)
NBL1-11974
Applications: WB
ILK Overexpression Lysate (Na ...
ILK Overexpression Lysate (Native)
NBL1-11975
Applications: WB
Proteins
Recombinant Human ILK Protein ...
Recombinant Human ILK Protein
H00003611-P01
Species: Hu
Applications: WB, ELISA, PA
ILK Recombinant Protein Antig ...
ILK Recombinant Protein Antigen
NBP2-55514PEP
Species: Hu
Applications: B/N, Ctrl
Recombinant Human ILK Protein ...
Recombinant Human ILK Protein
H00003611-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
ILK RNAi
ILK RNAi
H00003611-R01V
Species: Hu
Applications: WB, RNAi, RNAi SP
ILK RNAi
ILK RNAi
H00003611-R06
Species: Hu
Applications: RNAi, RNAi SP
ILK RNAi
ILK RNAi
H00003611-R04
Species: Hu
Applications: RNAi, RNAi SP

Description

Integrin-linked kinase (ILK) is a key cytoplasmic plaque protein involved in the mediation of integrin functions. It plays a key role as a regulator during cell survival, cell proliferation, cell migration, and cell to cell adhesion (1). ILK links integrins to the actin cytoskeleton, allowing transduction of signals through integrins to the extracellular matrix (ECM). Also, ILK has been linked to the regulation of smooth contraction and cell motility in non-muscle cells through phosphorylation of myosin (2). Irregular activity level of ILK has been linked to expression of certain tumor. ILK overexpression caused by inactivating mutation in tumor suppressors (e.g. PTEN and APC) lead to tumor formation in transgenic mouse. Up-regulated ILK expression and activity are seen in Ewings scaromas, colorectal cancers, and late staged prostate cancers (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 3611
Alternate Names
  • ILK2
  • P59
  • ILK1
  • p59ILK
  • EC 2.7.11.1
  • ILK-2
  • integrin-linked protein kinase
  • ILK-1
  • integrin-linked kinase-2
  • 59 kDa serine/threonine-protein kinase
  • DKFZp686F1765
  • integrin-linked kinase

Research Areas for ILK

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase
Signal Transduction

Bioinformatics Tool for ILK

Discover related pathways, diseases and genes to ILK. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related ILK Blog Posts

Check out the latest blog posts on ILK.
Inhibitor kappa B-alpha (IkappaB-alpha)
The transcription factor nuclear factor kappa beta (NFkB) is highly regulated by triggers such as stress, free-radicals, UV light, and hypoxia. NFkB is one of the fastest responding transcription factors in humans. The NFKB signaling pathway is ess...    Read more.
Read more ILK related blogs.