IL12B Products

Description

Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene.  The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo.  Chimera RNAi has many advantages over the conventional siRNAs.  First, it has been demonstrated to have reliable knock-down for over 10,000 human genes.  Because the human genome is composed of an intricate, genetic network, chimera RNAi's unique design has successfully obviated the off-target effects including microRNA-based influence.  Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected.  Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.

Bioinformatics

Product By Gene ID	3593
Alternate Names	CLMF p40 CLMF CLMF2 Cytotoxic lymphocyte maturation factor 40 kDa subunit IL-12 subunit p40 IL-12BNK cell stimulatory factor chain 2 interleukin 12, p40 interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocytematuration factor 2, p40) interleukin-12 beta chain interleukin-12 subunit beta natural killer cell stimulatory factor, 40 kD subunit NKSF NKSF2IL12, subunit p40

Research Areas for IL12B

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Immunology
Innate Immunity