IkB-epsilon Products

Antibodies
IkB-epsilon Antibody
IkB-epsilon Antibody
NBP1-87762
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
IkB-epsilon Antibody (418515) ...
IkB-epsilon Antibody (418515)
MAB4300
Species: Hu
Applications: WB
Host: Mouse Monoclonal
IkB-epsilon Antibody
IkB-epsilon Antibody
AF4637
Species: Mu
Applications: WB
Host: Sheep Polyclonal
Proteins
IkB-epsilon Partial Recombina ...
IkB-epsilon Partial Recombinant Pr...
H00004794-Q01
Species: Hu
Applications: WB, ELISA, PA
IkB-epsilon Recombinant Prote ...
IkB-epsilon Recombinant Protein An...
NBP1-87763PEP
Species: Hu
Applications: AC
IkB-epsilon Recombinant Prote ...
IkB-epsilon Recombinant Protein An...
NBP1-87762PEP
Species: Hu
Applications: AC
RNAi
IkB-epsilon RNAi
IkB-epsilon RNAi
H00004794-R01
Species: Hu

Description

The transcription factor NFkappaB is retained in the cytoplasm in an inactive form by the inhibitory protein IkappaB. Activation of NFkappaB requires that IkappaB be phosphorylated on specific serine residues, which results in targeted degradation of IkappaB. IkappaB kinase alpha (IKKalpha), previously designated CHUK, interacts with IkappaB-alpha and specifically phosphorylates IkappaB-alpha on the sites that trigger its degradation, Serines 32 and 36. IKKalpha appears to be critical for NFkappaB activation in response to proinflammatory cytokines. Phosphorylation of IkappaB by IKKalpha is stimulated by the NFkappaB inducing kinase (NIK), which itself is a central regulator for NFkappaB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKKalpha, IKKbeta and IKKgamma (also designated NEMO), and each appear to make essential contributions to IkappaB phosphorylation.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Product By Gene ID 4794
Alternate Names
  • ikB-epsilon
  • IkappaBepsilon
  • ikB-E
  • IkB-epsilon
  • NF-kappa-BIE
  • IkB-E
  • I-kappa-B-epsilon
  • IKBENF-kappa-B inhibitor epsilon
  • ikappaBepsilon
  • epsilon
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor

Research Areas for IkB-epsilon

Find related products by research area and learn more about each of the different research areas below.

Cancer
Phospho-Specific

PTMs for IkB-epsilon

Learn more about PTMs related to IkB-epsilon.

Phosphorylation
Reduction
Dephosphorylation

Bioinformatics Tool for IkB-epsilon

Discover related pathways, diseases and genes to IkB-epsilon. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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