IGF-II R/IGF2R Products

Antibodies
IGF-II R/IGF2R Antibody [Unco ...
IGF-II R/IGF2R Antibody [Unconjuga...
AF2447
Species: Hu
Applications: WB, Flow, IHC, B/N, CyTOF-ready
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
IGF-II R/IGF2R Antibody
IGF-II R/IGF2R Antibody
NB100-74387
Species: Hu, Mu, Bv, Pl, Pm
Applications: WB, DB, ICC/IF, TCS
Host: Rabbit Polyclonal
Proteins
Recombinant Human IGF-II R/IG ...
Recombinant Human IGF-II R/IGF2R P...
2447-GR
Species: Hu
Applications: Binding Activity
Formulation Catalog # Availability Price  
Recombinant Human IGF-II R/IG ...
Recombinant Human IGF-II R/IGF2R (...
6418-GR
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
IGF-II R/IGF2R Recombinant Pr ...
IGF-II R/IGF2R Recombinant Protein...
NBP1-84598PEP
Species: Hu
Applications: AC

Description

CD222 is a 250kDa transmembrane protein with a short cytoplasmic tail containing an internalization signal. CD222 was originally identified as a receptor for IGFII and M6P-containing proteins (e.g. lysosomal hydrolases). Lysosomal enzymes are sorted to lysosomes via CD222 either from the Golgi, where the enzymes acquire M6P, or from the extracellular space. The majority of CD222 molecules (approximately 90-95%) are located intracellularly, only 5-10% is present on the cell membrane. The internalization rate seems to be enhanced by ligand induced dimerization of CD222 as well as by phosphorylation of its cytoplasmic serine. CD222 is also a receptor for TGFbeta latency associated peptide (LAP), proliferin and may bind several molecules independently of M6P, including plasminogen, CD87 or retinoic acid. It is involved in activation of latent TGFbeta [PROW].

Bioinformatics

Entrez Human
Mouse
Rat
Bovine
Uniprot Human
Human
Bovine
Product By Gene ID 3482
Alternate Names
  • M6PR
  • CD222 antigen
  • CI-MPR
  • cation-independent mannose-6-phosphate receptor
  • 300 kDa mannose 6-phosphate receptor
  • cation-independent mannose-6 phosphate receptor
  • Insulin-like growth factor II receptor
  • MPR 300
  • MPR1
  • M6P/IGF2 receptor
  • M6P-R
  • IGF-II receptor
  • CIMPR
  • CI Man-6-P receptor
  • CD222
  • MPRIM6PR
  • insulin-like growth factor 2 receptorM6P/IGF2R

Research Areas for IGF-II R/IGF2R

Find related products by research area and learn more about each of the different research areas below.

Cancer
Golgi Apparatus Markers
Immunology
Innate Immunity

Bioinformatics Tool for IGF-II R/IGF2R

Discover related pathways, diseases and genes to IGF-II R/IGF2R. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.