IDH2 Products

Description

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.

Bioinformatics

Entrez	269951 Mouse 3418 Human 361596 Rat
Uniprot	NM_002168 Human NP_002159 Human NP_002159.2 Human P48735 Human
Product By Gene ID	3418
Alternate Names	D2HGA2 EC 1.1.1.42 ICD-M IDH IDHM IDP IDPM isocitrate dehydrogenase [NADP], mitochondrial isocitrate dehydrogenase 2 (NADP+), mitochondrial mNADP-IDH NADP(+)-specific ICDH Oxalosuccinate decarboxylase