ICEBERG Products

Description

ICEBERG consists essentially only of 1 CARD domain and is an inhibitor of pro-caspase 1 activation. It inhibits generation of IL-1b by interacting with caspase-1 and preventing association with RIP 2. ICEBERG functions as a competitive antagonist of RIP 2/pro-caspase 1 interactions and inhibits caspase 1-dependent pro-L-1b secretion in mononuclear cells. ICEBERG is induced by proinflammatory stimuli, suggesting that it may be part of a negative feedback loop.

Bioinformatics

Entrez	59082 Human
Uniprot	P57730 Human
Product By Gene ID	59082
Alternate Names	caspase recruitment domain family, member 18 Caspase-1 inhibitor Iceberg ICEBERG caspase-1 inhibitor ICEBERGcaspase recruitment domain-containing protein 18 pseudo-ICE UNQ5804

Research Areas for ICEBERG

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer