HYPB Products

Description

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. (provided by RefSeq)

Bioinformatics

Entrez	29072 Human 235626 Mouse
Uniprot	NP_054878.3 Human
Product By Gene ID	29072
Alternate Names	FLJ22472 FLJ23184 FLJ45883 FLJ46217 HIF1 HIF-1EC 2.1.1.43 HIP-1 histone-lysine N-methyltransferase SETD2 hSET2 huntingtin interacting protein 1 Huntingtin yeast partner B Huntingtin-interacting protein 1 Huntingtin-interacting protein B HYPBp231HBP KIAA1732SET domain-containing protein 2 KMT3AHBP231 Lysine N-methyltransferase 3A SET domain containing 2 SET2FLJ16420