Hyaluronidase 1/HYAL1 Products

Description

HYAL1 codes for a protein that may have a role in promoting tumor progression and blocking the TGFB1-enhanced cell growth, and is expressed highly in the liver, kidney, and heart, with weaker expression in the lung placenta, and skeletal muscle. There are seven isoforms of HYAL1, with the longest being isoform 1, which is only expressed in bladder and prostate cancer cells and is 435 amino acids long and weighs approximately 48 kDa. Current studies are being done on several diseases and disorders relating to this gene including lung carcinoma, lysosomal storage disease, diabetes mellitus, ovarian cancer, endometrial carcinoma, prostate cancer, and breast cancer. HYAL1 has also been shown to have interactions with GUSB, ARSB, IDUA, FAM107B, and COL2A1 in pathways such as the metabolic, lysosome, and Maroteaux-Lamy syndrome pathways.

Bioinformatics

Entrez	3373 Human
Uniprot	NM_033159 Human NP_695013 Human NP_695015.1 Human Q12794 Human
Product By Gene ID	3373
Alternate Names	EC 3.2.1.35 FUS2 Hyal-1 HYAL-1 hyaluronidase 1 hyaluronoglucosaminidase 1 hyaluronoglucosaminidase-1 Hyaluronoglucosaminidase-1 LuCa-1 luCa-1 LUCA1hyaluronidase-1 Lung carcinoma protein 1 MGC45987 NAT6 plasma hyaluronidase tumor suppressor LUCA-1