HSPB8/HSP22 Products

Description

HSP22 is encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.

Bioinformatics

Entrez	26353 Human 62353 Mouse
Uniprot	NM_014365 Human Q9UJY1 Human Q9UJY2 Human NP_055180 Human NP_055180.1 Human AAH02673 Human AAH02673.1 Human
Product By Gene ID	26353
Alternate Names	CRYAC Protein kinase H11 heat shock protein beta-8 Alpha-crystallin C chain HMN2 HspB8 HMN2A heat shock 27kDa protein 8 H11DHMN2 HSP22CMT2L E2IG1E2-induced gene 1 protein Small stress protein-like protein HSP22 heat shock 22kDa protein 8

Diseases related to HSPB8/HSP22

Discover more about diseases related to HSPB8/HSP22.

Charcot-marie-tooth Disease
Peripheral Motor Neuropathy
Neoplasms
Malignant Neoplasms
Neurodegenerative Disorders
Hereditary Motor And Sensory Neuropathies
Hypertrophy
Melanoma
Neuromuscular Diseases
Sclerosis
Myopathy
Alzheimer's Disease
Primary Lateral Sclerosis
Amyotrophic Lateral Sclerosis
Peripheral Neuropathy
Cardiac Hypertrophy
Myocardial Ischemia
Malignant Neoplasm Of Breast

Pathways for HSPB8/HSP22

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Autophagy
Cell Death
Cell Growth
Pathogenesis
Macroautophagy
Cell Proliferation
Dna Methylation
Transport
Methylation
Aging
Cell Cycle
Localization
Protein Folding
Translation
Demethylation
Programmed Cell Death
Proteolysis
Regulation Of Gene Expression
Oxidative Phosphorylation
Inflammatory Response

Research Areas for HSPB8/HSP22

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Protein Kinase

PTMs for HSPB8/HSP22

Learn more about PTMs related to HSPB8/HSP22.

Phosphorylation
Methylation
Demethylation
Cleavage
Oxidation
Ubiquitination

Bioinformatics Tool for HSPB8/HSP22

Discover related pathways, diseases and genes to HSPB8/HSP22. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.