HSP20/HSPB6 Products

Description

Hsp20 is a small heat shock protein related to Hsp25, Hsp27 and may form different hetercomplexes with these proteins. The specific physiological function of Hsp20 is not yet known. It is distributed ubiquitously in tissues, but is found in higher levels in skeletal, smooth and heart muscle. Under normal conditions, Hsp20 is diffusely distributed in the cytosol, but under heat stress conditions, it translocates to the nucleus. Unlike other heat shock proteins the amount of Hsp20 does not increase after heat shock. The Hsp20 was demonstrated to constitute up to 1.3% of the total cellular protein in vertebrate tissues, especially in muscle, and its expression is related to muscle contraction, specifically in slow-twitch muscle. Hsp20 may form different heterocomplexes with other Hsp's, such as alpha-crystalline and Hsp25. Phosphorylated form of Hsp20 is proposed to interact with monomeric actin whereas dephosphorylated form binds polymeric actin filaments. In normal conditions Hsp20 is diffusely disturbed in cytosol but under the heat stress it undergoes translocation to membrane fraction.

Bioinformatics

Entrez	126393 Human 192245 Rat 243912 Mouse
Uniprot	AAH68046 Human AAH68046.1 Human NM_144617 Human O14558 Human P97541 Rat
Product By Gene ID	126393
Alternate Names	FLJ32389 Heat shock 20 kDa-like protein p20 heat shock protein beta-6 heat shock protein, alpha-crystallin-related, B6 HSP20 Hsp20 HspB6