HSP20/HSPB6 Products

Description

Hsp20 is a small heat shock protein related to Hsp25, Hsp27 and may form different hetercomplexes with these proteins. The specific physiological function of Hsp20 is not yet known. It is distributed ubiquitously in tissues, but is found in higher levels in skeletal, smooth and heart muscle. Under normal conditions, Hsp20 is diffusely distributed in the cytosol, but under heat stress conditions, it translocates to the nucleus. Unlike other heat shock proteins the amount of Hsp20 does not increase after heat shock. The Hsp20 was demonstrated to constitute up to 1.3% of the total cellular protein in vertebrate tissues, especially in muscle, and its expression is related to muscle contraction, specifically in slow-twitch muscle. Hsp20 may form different heterocomplexes with other Hsp's, such as alpha-crystalline and Hsp25. Phosphorylated form of Hsp20 is proposed to interact with monomeric actin whereas dephosphorylated form binds polymeric actin filaments. In normal conditions Hsp20 is diffusely disturbed in cytosol but under the heat stress it undergoes translocation to membrane fraction.

Bioinformatics

Entrez	126393 Human 243912 Mouse 192245 Rat
Uniprot	O14558 Human NM_144617 Human AAH68046 Human AAH68046.1 Human P97541 Rat
Product By Gene ID	126393
Alternate Names	Heat shock 20 kDa-like protein p20 HSP20 Hsp20 HspB6 FLJ32389 heat shock protein beta-6 heat shock protein, alpha-crystallin-related, B6

Diseases related to HSP20/HSPB6

Discover more about diseases related to HSP20/HSPB6.

Observation Of Neuromuscular Block
Hypertrophy
Vasospasm
Dystrophy
Reperfusion Injury
Malignant Neoplasms
Pathologic Vasoconstriction
Physiological Stress
Heart Diseases
Myocardial Infarction
Cardiomyopathies
Thrombosis
Alzheimer's Disease
Cardiac Hypertrophy
Infectious Pustular Vulvovaginitis
Tumor Angiogenesis
Myotonic Dystrophy
Heart Failure
Cataract
Infarction

Pathways for HSP20/HSPB6

View related products by pathway and learn more about each of the pathways below.

Platelet Aggregation
Muscle Contraction
Smooth Muscle Contraction
Relaxation Of Vascular Smooth Muscle
Proteolysis
Cell Death
Tube Formation
Regulation Of Smooth Muscle Contraction
Protein Folding
Angiogenesis
Autophagy
Transport
Vascular Smooth Muscle Contraction
Hibernation
Muscle Cell Proliferation
Gene Silencing
Response To Morphine
Macroautophagy
Cell Motility
Regulation Of Proteolysis

PTMs for HSP20/HSPB6

Learn more about PTMs related to HSP20/HSPB6.

Phosphorylation
Dephosphorylation
Reduction
Acetylation
Methylation
Oxidation

Bioinformatics Tool for HSP20/HSPB6

Discover related pathways, diseases and genes to HSP20/HSPB6. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.