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HPRT is encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.
![Enzyme Activity HPRT [Unconjugated]](http://images.novusbio.com/fullsize2/HPRT_10314HP_2923.jpg)
![SDS-PAGE HPRT [Unconjugated]](http://images.novusbio.com/fullsize2/HPRT_10314HP_2922.jpg)