hnRNP F Products

Description

Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of polypeptides that contribute to pre-mRNA processing and transport, and also bind heterogeneous nuclear RNA (hnRNA), which are the transcripts produced by RNA polymerase II. hnRNP complexes are the major constituents of the spliceosome and in particular, the hnRNP A1 protein is one of the major premRNA/ mRNA binding proteins and also one of the most abundant proteins in the nucleus. hnRNP A1 and A2/B1 regulate the processing of pre-mRNA by directly antagonizing the association of various splicing factors and by influencing the splice site selection on pre-mRNA. The majority of hnRNP proteins components are localized to the nucleus; however some shuttle between the nucleus and the cytoplasm. Most hnRNP proteins, including hnRNP C1 and C2, contain one or more RNA binding domains and are implicated in the processing of pre-mRNA. hnRNPs F and H are largely related factors that preferentially associate with poly(rG) regions on RNA. Isoforms of these proteins are often generated by alternative processing of the premRNA and by posttranslational modifications such as phosphorylation on serines and threonines and methylation of arginines.

Bioinformatics

Entrez	3185 Human 64200 Rat
Uniprot	NP_001091674 Human NP_001091675 Human NP_001091676 Human NP_001091677 Human NP_001091678 Human NP_004957.1 Human P52597 Human
Product By Gene ID	3185
Alternate Names	heterogeneous nuclear ribonucleoprotein F hnRNP F HNRPFHnRNP F protein mcs94-1 MGC110997 Nucleolin-like protein mcs94-1 OK/SW-cl.23

Research Areas for hnRNP F

Find related products by research area and learn more about each of the different research areas below.

DNA Repair
DNA replication, Transcription, Translation and Splicing