HERC1 Products

Description

HERC1 (HECT domain and RCC1-like domain-containing protein 1) belongs to the HERC family of ubiquitin ligases. It is involved in membrane traffic via its ability to bind clathrin and its guanine nucleotide exchange factor (GEF) activity for Arf and Rab. HERC1 has been found to interact with TSC2 (tuberous sclerosis complex 2) and may be involved with its destabilization. Alternative names for HERC1 include p532 and p619.

Bioinformatics

Entrez	8925 Human
Uniprot	NP_003913.3 Human
Product By Gene ID	8925
Alternate Names	guanine nucleotide exchange factor p532 EC 6.3.2 HECT domain and RCC1-like domain-containing protein 1 p619EC 6.3.2.- p532probable E3 ubiquitin-protein ligase HERC1 hect domain and RCC1-like domain 1 hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1(CHC1)-like domain (RLD) 1

Diseases related to HERC1

Discover more about diseases related to HERC1.

Neoplasms
Malignant Neoplasms
Sclerosis
Carcinoma
Colorectal Cancer
Cell Transformation, Neoplastic
Angelman Syndrome
Tuberous Sclerosis
Stomach Neoplasms
Primary Lateral Sclerosis
Ataxia
Neuromuscular Diseases
Amyotrophic Lateral Sclerosis
Protein Deficiency
Pruritus
Lichen Disease
Hamartoma
Cytopathic Effect

Pathways for HERC1

View related products by pathway and learn more about each of the pathways below.

Cell Cycle
Transport
Cell Proliferation
Localization
Cytokinesis
Drug Resistance
Mismatch Repair
Translation
Cell Growth
Chromosome Condensation
Pathogenesis
Autophagy
Oncogenesis

PTMs for HERC1

Learn more about PTMs related to HERC1.

Phosphorylation
Myristoylation

Bioinformatics Tool for HERC1

Discover related pathways, diseases and genes to HERC1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.