Species: Hu
Applications: Flow, ICC/IF, PA
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Species: Hu, Ca, Eq
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, PA, AP
Species: Hu
Applications: AC
Description
Initiation of transcription from protein-coding genes in eukaryotes is a complex process that requires RNA polymerase II, as well as families of basal transcription factors. Binding of the factor TFIID (TBP) to the TATA box is believed to be the first step in the formation of a multiprotein complex containing several additional factors, including TFIIA, TFIIB, TFIIE, TFIIF and TFII. TFIIH (or BTF2) is a multisubunit transcription/DNA repair factor that possesses several enzymatic activities. The core of TFIIH is composed of five subunits, designated p89 (XPB or ERCC3), p62, p52, p44 and p34. Additional subunits of the TFIIH complex are p80 (XPD or ERCC2) and the ternary kinase complex composed of Cdk7, cyclin H and MAT1. Both p89 and p80 have ATP-dependent helicase activity. The p62, p52 and p44 subunits have been shown to be involved in nucleotide excision repair.
Bioinformatics
Entrez |
Human Mouse Rat |
Uniprot |
Human Human Human |
Product By Gene ID |
2966 |
Alternate Names |
- General transcription factor IIH polypeptide 2
- general transcription factor IIH, polypeptide 2, 44kD subunit
- Basic transcription factor 2 44 kDa subunit
- general transcription factor IIH subunit 2
- TFIIH
- MGC102806
- T-BTF2P44
- general transcription factor IIH, polypeptide 2 (44kD subunit)
- BTF2
- BTF2P44TFIIH basal transcription factor complex p44 subunit
- BTF2 p44
- general transcription factor IIH, polypeptide 2, 44kDa
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Pathways for GTF2H2
View related products by pathway and learn more about each of the pathways below.
Dna RepairTranslation
Research Areas for GTF2H2
Find related products by research area and learn more about each of the different research areas below.
Stem Cell Markers
Bioinformatics Tool for GTF2H2
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Bioinformatics Tool Guide for instructions on using this tool.