GTF2H2 Products

Description

Initiation of transcription from protein-coding genes in eukaryotes is a complex process that requires RNA polymerase II, as well as families of basal transcription factors. Binding of the factor TFIID (TBP) to the TATA box is believed to be the first step in the formation of a multiprotein complex containing several additional factors, including TFIIA, TFIIB, TFIIE, TFIIF and TFII. TFIIH (or BTF2) is a multisubunit transcription/DNA repair factor that possesses several enzymatic activities. The core of TFIIH is composed of five subunits, designated p89 (XPB or ERCC3), p62, p52, p44 and p34. Additional subunits of the TFIIH complex are p80 (XPD or ERCC2) and the ternary kinase complex composed of Cdk7, cyclin H and MAT1. Both p89 and p80 have ATP-dependent helicase activity. The p62, p52 and p44 subunits have been shown to be involved in nucleotide excision repair.

Bioinformatics

Entrez	2966 Human 23894 Mouse 294693 Rat
Uniprot	NP_001506.1 Human AAH05345 Human Q13888 Human
Product By Gene ID	2966
Alternate Names	General transcription factor IIH polypeptide 2 general transcription factor IIH, polypeptide 2, 44kD subunit Basic transcription factor 2 44 kDa subunit general transcription factor IIH subunit 2 TFIIH MGC102806 T-BTF2P44 general transcription factor IIH, polypeptide 2 (44kD subunit) BTF2 BTF2P44TFIIH basal transcription factor complex p44 subunit BTF2 p44 general transcription factor IIH, polypeptide 2, 44kDa

Diseases related to GTF2H2

Discover more about diseases related to GTF2H2.

Complete Hearing Loss
Malignant Neoplasms
Neoplasms
Non-small Cell Lung Carcinoma
Deafness Congenital
Muscular Atrophy
Atrophy
Radiation Induced Dna Damage
Spinal Muscular Atrophy
Malignant Neoplasm Of Lung
Spinal Muscular Atrophies Of Childhood

Pathways for GTF2H2

View related products by pathway and learn more about each of the pathways below.

Dna Repair
Translation

Research Areas for GTF2H2

Find related products by research area and learn more about each of the different research areas below.

Stem Cell Markers

Bioinformatics Tool for GTF2H2

Discover related pathways, diseases and genes to GTF2H2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.