GRP78/HSPA5 Products

GRP78/HSPA5 Overexpression Ly ...
GRP78/HSPA5 Overexpression Lysate
Species: Hu
Applications: WB
Recombinant Human GRP78/HSPA5 ...
Recombinant Human GRP78/HSPA5 GST ...
Species: Hu
Applications: WB, ELISA, Func, PA, AP
GRP78/HSPA5 Antibody Blocking ...
GRP78/HSPA5 Antibody Blocking Peptide
Species: Hu
Applications: AC
GRP78/HSPA5 Antibody Blocking ...
GRP78/HSPA5 Antibody Blocking Peptide
Species: Hu
Applications: AC


Within the ER, misfolded proteins are detected by Bip (GPR78). In the presence of misfolded proteins, GPR78 disscociates from PERK, allowing it to homodimerize and autophosphoyate. In its dimerized phosphorylated form, PERK phosphorylates eIF2. The phosphorylation of eIF2 blocks the majority of translation to prevent the continued accumulation of protein in the ER. GRP78 also binds to IRE1 and ATF6 under normal ER conditions, but dissociates upon accumulation of misfolded proteins. Unbound ATF6 is translocated to the gogli where it is converted into a cleaved, active form. The cleaved form of ATF6 is then able to up regulate transcription of UPR genes including XBP1. Activated IRE1 acts as an endoribonuclease to an intron from XBP1 transcripts. The XBP1 splice variant codes for an active transcription factor which activates transcription of P58IPK. P58IPK is a HSP40 protein which binds to and inhibits PERK. Thus, if the accumulated misfolded proteins have been removed, P58IPK acts to shut down the UPR by removing the block to translation.


Entrez Human
Uniprot Human
Product By Gene ID 3309
Alternate Names
  • Heat shock 70 kDa protein 5
  • heat shock 70kD protein 5 (glucose-regulated protein, 78kD)
  • GRP-78
  • Immunoglobulin heavy chain-binding protein
  • MIF2
  • Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
  • FLJ26106
  • BiP
  • GRP78BIP
  • 78 kDa glucose-regulated protein
  • heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)

Research Areas for GRP78/HSPA5

Find related products by research area and learn more about each of the different research areas below.

Cellular Markers
ER Markers
Lipid and Metabolism
Unfolded Protein Response

Bioinformatics Tool for GRP78/HSPA5

Discover related pathways, diseases and genes to GRP78/HSPA5. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Related GRP78/HSPA5 Blog Posts

Check out the latest blog posts on GRP78/HSPA5.
GRP78 - molecular chaperone and negative regulator of the unfolded protein response
The 78 kDa glucose-regulated protein (GRP78) is the eukaryotic orthologue to the prokaryotic heat shock 70 kDa protein 5 (HSPA5). GRP78 is also sometimes referred to as BiP. GRP78 is a member of the HSP70 family and plays dynamic roles in protein...    Read more.
Read more GRP78/HSPA5 related blogs.