GRP78/HSPA5 Products

Antibodies
GRP78/HSPA5 Antibody (474421) ...
GRP78/HSPA5 Antibody (474421)
MAB4846
Species: Hu
Applications: WB, Simple Western
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
ELISA Kits
Human GRP78/HSPA5 ELISA Kit ( ...
Human GRP78/HSPA5 ELISA Kit (Color...
NBP2-82201
Species: Hu
Applications: ELISA
Mouse GRP78/HSPA5 ELISA Kit ( ...
Mouse GRP78/HSPA5 ELISA Kit (Color...
NBP2-82202
Species: Mu
Applications: ELISA
Human, Mouse, Rat GRP78/HSPA5 ...
Human, Mouse, Rat GRP78/HSPA5 ELIS...
NBP2-62145
Species: Hu, Mu, Rt
Applications: ELISA
Lysates
GRP78/HSPA5 Overexpression Ly ...
GRP78/HSPA5 Overexpression Lysate
NBP2-10471
Species: Hu
Applications: WB
Proteins
Recombinant Human GRP78/HSPA5 ...
Recombinant Human GRP78/HSPA5 GST ...
H00003309-P01
Species: Hu
Applications: WB, ELISA, MA, AP
GRP78/HSPA5 Antibody Blocking ...
GRP78/HSPA5 Antibody Blocking Peptide
NBP1-06277PEP
Species: Hu
Applications: AC
GRP78/HSPA5 Antibody Blocking ...
GRP78/HSPA5 Antibody Blocking Peptide
NBP1-06274PEP
Species: Hu
Applications: AC

Description

Within the ER, misfolded proteins are detected by Bip (GPR78). In the presence of misfolded proteins, GPR78 disscociates from PERK, allowing it to homodimerize and autophosphoyate. In its dimerized phosphorylated form, PERK phosphorylates eIF2. The phosphorylation of eIF2 blocks the majority of translation to prevent the continued accumulation of protein in the ER. GRP78 also binds to IRE1 and ATF6 under normal ER conditions, but dissociates upon accumulation of misfolded proteins. Unbound ATF6 is translocated to the gogli where it is converted into a cleaved, active form. The cleaved form of ATF6 is then able to up regulate transcription of UPR genes including XBP1. Activated IRE1 acts as an endoribonuclease to an intron from XBP1 transcripts. The XBP1 splice variant codes for an active transcription factor which activates transcription of P58IPK. P58IPK is a HSP40 protein which binds to and inhibits PERK. Thus, if the accumulated misfolded proteins have been removed, P58IPK acts to shut down the UPR by removing the block to translation.

Bioinformatics

Entrez Mouse
Rat
Human
Uniprot Human
Human
Human
Rat
Human
Alternate Names
  • 78 kDa glucose-regulated protein
  • BiP
  • Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
  • FLJ26106
  • GRP-78
  • GRP78BIP
  • Heat shock 70 kDa protein 5
  • heat shock 70kD protein 5 (glucose-regulated protein, 78kD)
  • heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
  • Immunoglobulin heavy chain-binding protein
  • MIF2

Research Areas for GRP78/HSPA5

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cellular Markers
ER Markers
Lipid and Metabolism
Unfolded Protein Response