GPR154 Products

Description

The GPR154 gene codes a neuropeptide S receptor plasma membrane protein as it is part of the G protein-coupled receptor 1 family. The protein encoded by the GPR154 gene is active in signaling pathway in several tissues in a paracrine or autocrine fashion through mediation of inhibitory effects on cell growth. Nine isoforms of this protein exist: isoform 1: 371 amino acids long, 42 kDA; isoform 2: 305 amino acids long, 35 kDA; isoform 3: 390 amino acids long, 44 kDA; isoform 4: 377 amino acids long, 43 kDA; isoform 5: 366 amino acids long, 41 kDA; isoform 6: 158 amino acids long, 18 kDA; isoform 7: 136 amino acids long, 15 kDA; isoform 8: 143 amino acids long, 16 kDA; and isoform 9: 94 amino acids long, 10 kDA; It is known to be involved in the pathogenesis of asthma and other IgE-mediated diseases because of increased expression in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells. Research has investigated its role in asthma, panic disorder, dermatitis, rabies, eczema, inflammatory bowel disease, rheumatoid arthritis, schizophrenia, and attention deficit hyperactivity disorder as well. The GPR154 gene participates in GPCR downstream signaling and ligand binding through interactions with various genes such as: ADYC2, ADORA2A, ADORA2B, ADRB2, and AVPR1B.

Bioinformatics

Entrez	387129 Human
Uniprot	NP_997056 Human Q6W5P4 Human NM_207172 Human
Product By Gene ID	387129
Alternate Names	vasopressin receptor-related receptor 1 G-protein coupled receptor for asthma susceptibility neuropeptide S receptor G-protein coupled receptor 154 G protein-coupled receptor for asthma susceptibility G protein-coupled receptor 154 GPR154NPSR PGR14VRR1 GPRAASRT2 G-protein coupled receptor PGR14 neuropeptide S receptor 1

Diseases related to GPR154

Discover more about diseases related to GPR154.

Asthma
Anxiety Disorders
Inflammation
Panic Disorder
Allergic Asthma
Allergy
Inflammatory Bowel Diseases
Intestinal Diseases
Bronchial Hyperreactivity
Pain
Rheumatoid Arthritis
Dysequilibrium Syndrome
Arthritis
Rhinorrhea
Dermatitis, Atopic
Immediate Hypersensitivity
Schizophrenia
Lung Diseases
Childhood Asthma
Eczema

Pathways for GPR154

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Pathogenesis
Locomotion
Reflex
Righting Reflex
Prepulse Inhibition
Startle Response
Swimming
Response To Stress
Transport
Cell Activation
Habituation
T Cell Activation
Immune Response
Sensitization
Phagocytosis
Monocyte Activation
Hormone Secretion
Circadian Rhythm
Dna Methylation
Glycosylation

Research Areas for GPR154

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GPCR

PTMs for GPR154

Learn more about PTMs related to GPR154.

Glycosylation
Citrullination

Bioinformatics Tool for GPR154

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