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GPCR GPR12 is a G protein coupled receptor. A variety of extracellular signals are transmitted into cells through integral membrane receptors coupled to heterotrimeric G proteins. Such G protein coupled receptors are critical for the normal functions of many cell types: neurons, endocrine cells, cardiac and smooth muscle cells, and sensory cells for detection of light, taste, and smell. Both activating and loss of function mutations in G protein coupled receptors have been found as the cause of human diseases. The GPR12 gene is located on human chromosome 13q12. GPR12 expression has been reported primarily in the central nervous system. Rat transcripts have been identified at low levels in testis and pituitary gland. ESTs have been isolated from human brain and eye libraries, as well as mouse brain.
![Immunohistochemistry GPR12 Antibody (584940) [Unconjugated]](http://images.novusbio.com/fullsize2/GPR12_MAB6738_Immunohistochemistry_10817.jpg)
-Western Blot-NBP2-04285-img0001.jpg)
![Flow Cytometry GPR12 Antibody (584940) [Unconjugated]](http://images.novusbio.com/fullsize2/GPR12_MAB6738_Flow_Cytometry_22082.jpg)
