Glutathione S-Transferase pi 1/GSTP1 Products

Description

GSTP1 (glutathione-S-transferase, pi 1), also called GST3/DFN7, which is located on chromosome 11q13 , is a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. GSTP1 act like a tumor suppressor gene, which when inactivated leads to tumor growth, and the -class glutathione S-transferase is commonly inactivated by somatic CpGisland hypermethylation in cancers of the prostate, liver, and breast. Methylation of regulatory sequences at the GSTP1 gene locus is found in the vast majority (>90%) of prostate carcinomas and is associated with transcriptional down-regulation.

Bioinformatics

Entrez	14870 Mouse 24426 Rat 2950 Human
Uniprot	AAH10915 Human AAH10915.1 Human NM_000852 Human NP_000843 Human NP_000843.1 Human P09211 Human
Product By Gene ID	2950
Alternate Names	deafness, X-linked 7 EC 2.5.1.18 FAEES3 fatty acid ethyl ester synthase III glutathione S-transferase P glutathione S-transferase pi 1 GST class-pi GST3DFN7 GSTP GSTP1-1 PI

Research Areas for Glutathione S-Transferase pi 1/GSTP1

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