Species: Hu, Mu, Rt, Ca
Applications: ELISA, IHC
Host: Goat Polyclonal
Species: Hu
Applications: WB, ICC/IF, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
GGA3 encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network (TGN) and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma- adaptins. GGA3 mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. Alternative splicing of this gene results in two transcript variants.
Bioinformatics
| Entrez |
Human
Mouse
Rat
Chicken
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
23163 |
| Alternate Names |
- ADP-ribosylation factor-binding protein GGA3
- golgi associated, gamma adaptin ear containing, ARF binding protein 3
- golgi-associated, gamma adaptin ear containing, ARF binding protein 3
- KIAA0154Golgi-localized, gamma ear-containing, ARF-binding protein 3
|
