GCH1 Products

Antibodies
GCH1 Antibody
GCH1 Antibody
NBP1-84949
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
GCH1 Antibody
GCH1 Antibody
H00002643-B01P
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Polyclonal
GCH1 Antibody
GCH1 Antibody
NBP1-20923
Species: Hu
Applications: WB, PEP-ELISA
Host: Goat Polyclonal
Antibody Pairs
GCH1 Antibody Pair
GCH1 Antibody Pair
H00002643-PW1
Species: Hu
Applications: WB, IP
GCH1 Antibody Pair
GCH1 Antibody Pair
H00002643-AP11
Species: Hu
Applications: S-ELISA
Lysates
GCH1 Overexpression Lysate (D ...
GCH1 Overexpression Lysate (Denatu...
H00002643-T01
Species: Hu
Applications: WB
GCH1 Overexpression Lysate (N ...
GCH1 Overexpression Lysate (Native)
NBP2-08654
Applications: WB
GCH1 Overexpression Lysate (N ...
GCH1 Overexpression Lysate (Native)
NBL1-11007
Applications: WB
Proteins
GCH1 Recombinant Protein
GCH1 Recombinant Protein
H00002643-P01
Species: Hu
Applications: WB, ELISA, PA
GCH1 Partial Recombinant Prot ...
GCH1 Partial Recombinant Protein
H00002643-Q01
Species: Hu
Applications: WB, ELISA, PA
GCH1 Recombinant Protein Anti ...
GCH1 Recombinant Protein Antigen
NBP1-84949PEP
Species: Hu
Applications: AC
RNAi
GCH1 RNAi
GCH1 RNAi
H00002643-R02
Species: Hu
GCH1 RNAi
GCH1 RNAi
H00002643-R04
Species: Hu
GCH1 RNAi
GCH1 RNAi
H00002643-R01
Species: Hu

Description

GCH1 encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 2643
Alternate Names
  • GTP-CH-I
  • guanosine 5'-triphosphate cyclohydrolase I
  • GCH
  • GTP-CH-1
  • dystonia 14
  • DYT14
  • GTPCH1
  • HPABH4B
  • DYT5a
  • DYT5EC 3.5.4.16
  • GTP cyclohydrolase I
  • GTP cyclohydrolase 1

Bioinformatics Tool for GCH1

Discover related pathways, diseases and genes to GCH1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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