GAD2/GAD65 Products

Description

Antibodies to glutamic acid decarboxylase-65 (GAD65) are present in autoimmune disorders such as insulin-dependent (type 1) diabetes mellitus (IDDM), stiff man syndrome and polyendocrine autoimmune disease. Auto-antibodies to GAD65 are present in 60-70% of individuals with newly diagnosed IDDM and thus are important markers for disease activity. These auto-antibodies usually recognize conformation-dependent regions on GAD65 and rarely bind to the second isoform, GAD67. Auto-antibodies to GAD67 are found in only 15% of recent-onset IDDM patients and most of this binding can be blocked with GAD65, suggesting shared epitopes between the two isoforms of GAD.

Bioinformatics

Entrez	14417 Mouse 24380 Rat 2572 Human
Uniprot	NP_000809 Human NP_000809.1 Human NP_000809.1. Human NP_001127838 Human Q05329 Human
Product By Gene ID	2572
Alternate Names	EC 4.1.1 EC 4.1.1.15 GAD-65 GAD65MGC161605 glutamate decarboxylase 2 (pancreatic islets and brain, 65kD) glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) glutamate decarboxylase 2 Glutamate decarboxylase 65 kDa isoform Glutamate decarboxylase-2 (pancreas) MGC161607,65 kDa glutamic acid decarboxylase

Research Areas for GAD2/GAD65

Find related products by research area and learn more about each of the different research areas below.

Diabetes Research
Immune System Diseases
Immunology
Lipid and Metabolism
Neuronal Cell Markers
Neuroscience