Species: Hu, Mu, Rt, Po, Ha, Pm
Applications: WB, Func, IHC, MA
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ELISA, Flow, CyTOF-ready
Host: Mouse Monoclonal
Species: Pm
Applications: ELISA
Description
Antibodies to glutamic acid decarboxylase-65 (GAD65) are present in autoimmune disorders such as insulin-dependent (type 1) diabetes mellitus (IDDM), stiff man syndrome and polyendocrine autoimmune disease. Auto-antibodies to GAD65 are present in 60-70% of individuals with newly diagnosed IDDM and thus are important markers for disease activity. These auto-antibodies usually recognize conformation-dependent regions on GAD65 and rarely bind to the second isoform, GAD67. Auto-antibodies to GAD67 are found in only 15% of recent-onset IDDM patients and most of this binding can be blocked with GAD65, suggesting shared epitopes between the two isoforms of GAD.
Bioinformatics
| Product By Gene ID |
2572 |
| Alternate Names |
- EC 4.1.1
- EC 4.1.1.15
- GAD2
- GAD65
- GAD-65
- GAD65MGC161605
- glutamate decarboxylase 2 (pancreatic islets and brain, 65kD)
- glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
- glutamate decarboxylase 2
- Glutamate decarboxylase 65 kDa isoform
- Glutamate decarboxylase-2 (pancreas)
- MGC161607,65 kDa glutamic acid decarboxylase
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