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5925-FS) induces cAMP production in the HEK293 human embryonic kidney cell line transfected with human FSH R in a dose-dependent manner (orange line), as measured by the cAMP Parameter Assay Kit (Catalog # KGE002B). cAMP production elicited by Recom-binant Human FSH a/ beta (1 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human FSH R Monoclonal Antibody (Catalog # MAB65591). The ND50 is typically 0.02-0.1 µg/mL." class="big_lightbox" target="_blank">
Follicle-stimulating hormone (FSH), also called follitropin, belongs to the family of glycoprotein hormones that also includes luteininizing hormone and thyroid-stimulating hormone. These hormones are secreted by the pituitary and exist as heterodimers, consisting of a common alpha subunit and a homologous but distinct beta subunit. While the alpha subunit of FSH is involved in the binding of FSH to the receptor, follicle-stimulating hormone receptor (FSHR), the beta subunit stabilizes this interaction. This heterodimer regulates a variety of processes, including secretion, post-translational modification and signal transduction. Both FSH and FSHR are localized to Sertoli cells.
![Flow Cytometry FSHR Antibody (626717) [Unconjugated]](http://images.novusbio.com/images/antibody/FSH_R_MAB65591_Flow_Cytometry_21765.jpg)
![Immunohistochemistry FSHR Antibody (626723) [Unconjugated]](http://images.novusbio.com/images/antibody/FSH_R_MAB6559_Immunohistochemistry_10456.jpg)
![Neutralization FSHR Antibody (626717) [Unconjugated]](http://images.novusbio.com/images/antibody/FSH_R_MAB65591_Block_Neutralize_10415.jpg)
