FMO5 Products

Description

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.

Bioinformatics

Entrez	2330 Human
Uniprot	AAH35687 Human
Product By Gene ID	2330
Alternate Names	dimethylaniline monooxygenase [N-oxide-forming] 5 Dimethylaniline oxidase 5 EC 1.14.13.8 flavin containing monooxygenase 5 FMO 5 Hepatic flavin-containing monooxygenase 5

Research Areas for FMO5

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Cancer